Dose-dependent pharmacokinetics of PMM in the rat

Tina Colombo; Laura Torti; Maurizio D'Incalci

doi:10.1007/BF00258481

Dose-dependent pharmacokinetics of PMM in the rat

Tina Colombo, Laura Torti, Maurizio D'Incalci

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 μg/mlxmin; plasma clearances were 0.042 and 0.027 l·kg^-1·min^-1, respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

Original language	English
Pages (from-to)	201-203
Number of pages	3
Journal	Cancer Chemotherapy and Pharmacology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/BF00258481
Publication status	Published - 1981

ASJC Scopus subject areas

Cancer Research
Oncology
Pharmacology

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title = "Dose-dependent pharmacokinetics of PMM in the rat",

abstract = "Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 μg/mlxmin; plasma clearances were 0.042 and 0.027 l·kg-1·min-1, respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.",

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AB - Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 μg/mlxmin; plasma clearances were 0.042 and 0.027 l·kg-1·min-1, respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

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