Dose-dependent pharmacokinetics of PMM in the rat

Tina Colombo, Laura Torti, Maurizio D'Incalci

Research output: Contribution to journalArticlepeer-review

Abstract

Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 μg/mlxmin; plasma clearances were 0.042 and 0.027 l·kg-1·min-1, respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume5
Issue number3
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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