Dose intensity analysis in advanced ovarian cancer patients

V. Torri, E. L. Korn, R. Simon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To determine if chemotherapy dose intensity influences treatment outcome in advanced ovarian cancer, all randomised studies of first line chemotherapy, published between 1975 and 1989, were analysed for relationships between planned dose intensity and (a) objective response and (b) median survival. Total dose intensity of each study regimen was calculated and a weighted regression model providing for systemic differences in response or survival among studies was utilised. Hence, treatment arms of different studies were never directly compared. In addition, relative dose intensities of individual drugs within combinations was similarly evaluated. The improvement in objective response rate when adding one unit of total dose intensity ranged between 12% and 16% depending on baseline response rate. The improvement in median survival when adding one unit of total dose intensity ranged between 2 and 4 months. One unit of total dose intensity corresponds to, for example, 20 mg m2 week of cisplatin, or 25 mg m2 week of doxorubicin, or 350 mg m2 week of cyclophosphamide. The analysis of individual drugs suggested that doxorubicin and the platinum compounds were about equally effective, with cyclophosphamide being less effective. The methodological benefits and limitations of the approach used and the implication of the results are discussed.

Original languageEnglish
Pages (from-to)190-197
Number of pages8
JournalBritish Journal of Cancer
Volume67
Issue number1
Publication statusPublished - Jan 1993

Fingerprint

Ovarian Neoplasms
Doxorubicin
Cyclophosphamide
Survival
Platinum Compounds
Drug Therapy
Drug Combinations
Cisplatin
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dose intensity analysis in advanced ovarian cancer patients. / Torri, V.; Korn, E. L.; Simon, R.

In: British Journal of Cancer, Vol. 67, No. 1, 01.1993, p. 190-197.

Research output: Contribution to journalArticle

Torri, V, Korn, EL & Simon, R 1993, 'Dose intensity analysis in advanced ovarian cancer patients', British Journal of Cancer, vol. 67, no. 1, pp. 190-197.
Torri, V. ; Korn, E. L. ; Simon, R. / Dose intensity analysis in advanced ovarian cancer patients. In: British Journal of Cancer. 1993 ; Vol. 67, No. 1. pp. 190-197.
@article{cae748a9a9d94cf993c7a1b076427ce9,
title = "Dose intensity analysis in advanced ovarian cancer patients",
abstract = "To determine if chemotherapy dose intensity influences treatment outcome in advanced ovarian cancer, all randomised studies of first line chemotherapy, published between 1975 and 1989, were analysed for relationships between planned dose intensity and (a) objective response and (b) median survival. Total dose intensity of each study regimen was calculated and a weighted regression model providing for systemic differences in response or survival among studies was utilised. Hence, treatment arms of different studies were never directly compared. In addition, relative dose intensities of individual drugs within combinations was similarly evaluated. The improvement in objective response rate when adding one unit of total dose intensity ranged between 12{\%} and 16{\%} depending on baseline response rate. The improvement in median survival when adding one unit of total dose intensity ranged between 2 and 4 months. One unit of total dose intensity corresponds to, for example, 20 mg m2 week of cisplatin, or 25 mg m2 week of doxorubicin, or 350 mg m2 week of cyclophosphamide. The analysis of individual drugs suggested that doxorubicin and the platinum compounds were about equally effective, with cyclophosphamide being less effective. The methodological benefits and limitations of the approach used and the implication of the results are discussed.",
author = "V. Torri and Korn, {E. L.} and R. Simon",
year = "1993",
month = "1",
language = "English",
volume = "67",
pages = "190--197",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Dose intensity analysis in advanced ovarian cancer patients

AU - Torri, V.

AU - Korn, E. L.

AU - Simon, R.

PY - 1993/1

Y1 - 1993/1

N2 - To determine if chemotherapy dose intensity influences treatment outcome in advanced ovarian cancer, all randomised studies of first line chemotherapy, published between 1975 and 1989, were analysed for relationships between planned dose intensity and (a) objective response and (b) median survival. Total dose intensity of each study regimen was calculated and a weighted regression model providing for systemic differences in response or survival among studies was utilised. Hence, treatment arms of different studies were never directly compared. In addition, relative dose intensities of individual drugs within combinations was similarly evaluated. The improvement in objective response rate when adding one unit of total dose intensity ranged between 12% and 16% depending on baseline response rate. The improvement in median survival when adding one unit of total dose intensity ranged between 2 and 4 months. One unit of total dose intensity corresponds to, for example, 20 mg m2 week of cisplatin, or 25 mg m2 week of doxorubicin, or 350 mg m2 week of cyclophosphamide. The analysis of individual drugs suggested that doxorubicin and the platinum compounds were about equally effective, with cyclophosphamide being less effective. The methodological benefits and limitations of the approach used and the implication of the results are discussed.

AB - To determine if chemotherapy dose intensity influences treatment outcome in advanced ovarian cancer, all randomised studies of first line chemotherapy, published between 1975 and 1989, were analysed for relationships between planned dose intensity and (a) objective response and (b) median survival. Total dose intensity of each study regimen was calculated and a weighted regression model providing for systemic differences in response or survival among studies was utilised. Hence, treatment arms of different studies were never directly compared. In addition, relative dose intensities of individual drugs within combinations was similarly evaluated. The improvement in objective response rate when adding one unit of total dose intensity ranged between 12% and 16% depending on baseline response rate. The improvement in median survival when adding one unit of total dose intensity ranged between 2 and 4 months. One unit of total dose intensity corresponds to, for example, 20 mg m2 week of cisplatin, or 25 mg m2 week of doxorubicin, or 350 mg m2 week of cyclophosphamide. The analysis of individual drugs suggested that doxorubicin and the platinum compounds were about equally effective, with cyclophosphamide being less effective. The methodological benefits and limitations of the approach used and the implication of the results are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027459748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027459748&partnerID=8YFLogxK

M3 - Article

C2 - 8427779

AN - SCOPUS:0027459748

VL - 67

SP - 190

EP - 197

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 1

ER -