Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man

G. Franceschini, J. P. Werba, O. Safa, I. Gikalov, C. R. Sirtori

Research output: Contribution to journalArticle

Abstract

Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalPharmacological Research
Volume28
Issue number3
DOIs
Publication statusPublished - 1993

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Keywords

  • HDL-cholesterol
  • Lipoprotein (a)
  • N-acetylcysteine

ASJC Scopus subject areas

  • Pharmacology

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