Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man

G. Franceschini; J. P. Werba; O. Safa; I. Gikalov; C. R. Sirtori

doi:10.1006/phrs.1993.1124

Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man

G. Franceschini, J. P. Werba, O. Safa, I. Gikalov, C. R. Sirtori

Centro Cardiologico Monzino

Research output: Contribution to journal › Article

Abstract

Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day^-1 to 3600 mg day^-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl^-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.

Original language	English
Pages (from-to)	213-218
Number of pages	6
Journal	Pharmacological Research
Volume	28
Issue number	3
DOIs	https://doi.org/10.1006/phrs.1993.1124
Publication status	Published - 1993

Fingerprint

Keywords

HDL-cholesterol
Lipoprotein (a)
N-acetylcysteine

ASJC Scopus subject areas

Pharmacology

Cite this

Franceschini, G., Werba, J. P., Safa, O., Gikalov, I., & Sirtori, C. R. (1993). Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man. Pharmacological Research, 28(3), 213-218. https://doi.org/10.1006/phrs.1993.1124

@article{1e52a0c20936493fa6974179bb37da1f,

title = "Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man",

abstract = "Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.",

keywords = "HDL-cholesterol, Lipoprotein (a), N-acetylcysteine",

author = "G. Franceschini and Werba, {J. P.} and O. Safa and I. Gikalov and Sirtori, {C. R.}",

year = "1993",

doi = "10.1006/phrs.1993.1124",

language = "English",

volume = "28",

pages = "213--218",

journal = "Pharmacological Research",

issn = "1043-6618",

publisher = "Academic Press",

number = "3",

}

TY - JOUR

T1 - Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man

AU - Franceschini, G.

AU - Werba, J. P.

AU - Safa, O.

AU - Gikalov, I.

AU - Sirtori, C. R.

PY - 1993

Y1 - 1993

N2 - Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.

AB - Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.

KW - HDL-cholesterol

KW - Lipoprotein (a)

KW - N-acetylcysteine

UR - http://www.scopus.com/inward/record.url?scp=0027385607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027385607&partnerID=8YFLogxK

U2 - 10.1006/phrs.1993.1124

DO - 10.1006/phrs.1993.1124

M3 - Article

C2 - 8108311

AN - SCOPUS:0027385607

VL - 28

SP - 213

EP - 218

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 3

ER -

Access to Document

10.1006/phrs.1993.1124