TY - JOUR
T1 - Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man
AU - Franceschini, G.
AU - Werba, J. P.
AU - Safa, O.
AU - Gikalov, I.
AU - Sirtori, C. R.
PY - 1993
Y1 - 1993
N2 - Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.
AB - Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1 of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.
KW - HDL-cholesterol
KW - Lipoprotein (a)
KW - N-acetylcysteine
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U2 - 10.1006/phrs.1993.1124
DO - 10.1006/phrs.1993.1124
M3 - Article
C2 - 8108311
AN - SCOPUS:0027385607
VL - 28
SP - 213
EP - 218
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 3
ER -