Dose-response effectiveness of gallopamil for the treatment of chronic stable effort angina pectoris: Comparison with propranolol

D. Scrutinio, R. Lagioia, D. Accettura

Research output: Contribution to journalArticle

Abstract

In this double-blind randomized placebo-controlled trial, the effects of two single doses of gallopamil (50 and 100 mg) were compared with those of propranolol 80 mg in 12 patients with chronic stable effort angina. An exercise bicycle test was performed 2 and 7 hours after acute oral administration of the medications. Mean exercise time with placebo was 387 ± 123 and 400 ± 120 seconds 2 and 7 hours after administration, respectively; the mean -1 mm time was 285 ± 106 and 269 ± 85 seconds. Propranolol increased mean exercise time to 474 ± 98 (p: NS) and 470 ± 120 seconds (p: NS) and the mean -1 mm time to 388 ± 84 (p <0.05) and 357 ± 98 seconds (p: NS) 2 and 7 hours after administration, respectively. Gallopamil 50 mg increased the mean exercise time to 525 ± 150 (p <0.05) and 467 ± 128 seconds (p: NS) and the mean -1 mm time to 422 ± 120 (p <0.05) and 304 ± 69 seconds (p: NS) 2 and 7 hours after administration. Gallopamil 100 mg increased the mean exercise time to 550 ± 164 (p <0.05) and 490 ± 151 seconds (p: NS) and the mean -1 mm time to 490 ± 159 (p <0.01) and 362 ± 111 seconds (p: NS) 2 and 7 hours after administration. At the highest common level of work, ST-segment depression as well as rate-pressure product were substantially reduced by both propranolol and gallopamil 2 hours after administration, whereas at 7 hours reductions were less marked. Maximal rate-pressure product was reduced by propranolol but was slightly increased by gallopamil. In conclusion, our data show the effectiveness of gallopamil in the treatment of chronic stable effort angina and support the opportunity of using the high dose that was found to be more effective than propranolol 80 mg. The effects of gallopamil 100 mg at 7 hours, though substantially similar to those of propranolol, were less marked than at 2 hours suggesting that the calcium-antagonist should be administered at least 3 times daily. Further studies are needed to assess the dose-response effectiveness and the adverse reaction during chronic treatment.

Original languageEnglish
Pages (from-to)830-842
Number of pages13
JournalCurrent Therapeutic Research
Volume37
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Dose-response effectiveness of gallopamil for the treatment of chronic stable effort angina pectoris: Comparison with propranolol'. Together they form a unique fingerprint.

  • Cite this