Dose-response efficacy of paroxetine in preventing depressive recurrences: A randomized, double-blind study

Linda Franchini, Mariangela Gasperini, Jorge Perez, Enrico Smeraldi, Raffaella Zanardi

Research output: Contribution to journalArticle

Abstract

Background: The authors evaluated and compared the efficacy of 20 mg versus 40 mg of paroxetine in a randomized, double-blind, parallel-group study during a maintenance period of 28 months. Method: Ninety-nine inpatients with recurrent, unipolar depression (DSM-IV criteria) who had at least 1 depressive episode during the 18 months preceding the index episode were openly treated with paroxetine 40 mg/day. Seventy-two subjects had a stable response (Hamilton Rating Scale for Depression score <8) to paroxetine treatment and remained in the continuation treatment as outpatients for 4 months. At the time of recovery, 68 patients were randomly assigned to 1 of the 2 maintenance treatment groups: paroxetine 20 mg or paroxetine 40 mg daily. Results: Sixty-seven patients completed the 28-month follow-up period. Seventeen (51.5%) of 33 patients in the 20-mg paroxetine regimen had a single recurrence compared with 8 (23.5%) of 34 subjects in the 40-mg dose regimen (χ2 = 5.56, p = .018). Conclusion: These data suggest that a full dose of paroxetine is recommended in unipolar patients who are at high risk for recurrent depressive episodes.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalJournal of Clinical Psychiatry
Volume59
Issue number5
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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    Franchini, L., Gasperini, M., Perez, J., Smeraldi, E., & Zanardi, R. (1998). Dose-response efficacy of paroxetine in preventing depressive recurrences: A randomized, double-blind study. Journal of Clinical Psychiatry, 59(5), 229-232.