Dosimetric and clinical advantages of deep inspiration breath-hold (DIBH) during radiotherapy of breast cancer

Vicente Bruzzaniti, Armando Abate, Paola Pinnarò, Marco D'Andrea, Erminia Infusino, Valeria Landoni, Antonella Soriani, Carolina Giordano, Anna Maria Ferraro, Lidia Strigari

Research output: Contribution to journalArticlepeer-review


Background: To investigate the potential dosimetric and clinical benefits of Deep Inspiration Breath-Hold (DIBH) technique during radiotherapy of breast cancer compared with Free Breathing (FB). Methods. Eight left-sided breast cancer patients underwent a supervised breath hold during treatment. For each patient, two CT scans were acquired with and without breath hold, and virtual simulation was performed for conventional tangential fields, utilizing 6 or 15 MV photon fields. The resulting dose-volume histograms were calculated, and the volumes of heart/lung irradiated to given doses were assessed. The left anterior descending coronary artery (LAD) mean and maximum doses were calculated, together with tumour control probability (TCP) and normal tissue complication probabilities (NTCP) for lung and heart. Results: For all patients a reduction of at least 16% in lung mean dose and at least 20% in irradiated pulmonary volumes was observed when DIBH was applied. Heart and LAD maximum doses were decreased by more than 78% with DIBH. The NTCP values for pneumonitis and long term cardiac mortality were also reduced by about 11% with DIBH. The NTCP values for pericarditis were zero for both DIBH and FB. Conclusion: Delivering radiation in DIBH conditions the dose to the surrounding normal structures could be reduced, in particular heart, LAD and lung, due to increased distance between target and heart, and to reduced lung density.

Original languageEnglish
Article number88
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
Publication statusPublished - 2013


  • Breast cancer radiotherapy
  • Deep inspiration breath-hold gating radiotherapy
  • NTCP
  • TCP

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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