Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy

Antonella Fogliata, Marta Scorsetti, Piera Navarria, Maddalena Catalano, Alessandro Clivio, Luca Cozzi, Francesca Lobefalo, Giorgia Nicolini, Valentina Palumbo, Chiara Pellegrini, Giacomo Reggiori, Antonella Roggio, Eugenio Vanetti, Filippo Alongi, Sara Pentimalli, Pietro Mancosu

Research output: Contribution to journalArticlepeer-review

Abstract

Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3

Original languageEnglish
Pages (from-to)545-552
Number of pages8
JournalActa Oncologica
Volume52
Issue number3
DOIs
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

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