Dosimetric verification of stereotactic radiosurgery/stereotactic radiotherapy dose distributions using Gafchromic EBT3

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim of this study is to examine the feasibility of using the new Gafchromic EBT3 film in a high-dose stereotactic radiosurgery and radiotherapy quality assurance procedure. Owing to the reduced dimensions of the involved lesions, the feasibility of scanning plan verification films on the scanner plate area with the best uniformity rather than using a correction mask was evaluated. For this purpose, signal values dispersion and reproducibility of film scans were investigated. Uniformity was then quantified in the selected area and was found to be within 1.5% for doses up to 8. Gy. A high-dose threshold level for analyses using this procedure was established evaluating the sensitivity of the irradiated films. Sensitivity was found to be of the order of centiGray for doses up to 6.2. Gy and decreasing for higher doses. The obtained results were used to implement a procedure comparing dose distributions delivered with a CyberKnife system to planned ones. The procedure was validated through single beam irradiation on a Gafchromic film. The agreement between dose distributions was then evaluated for 13 patients (brain lesions, 5. Gy/die prescription isodose ~80%) using gamma analysis. Results obtained using Gamma test criteria of 5%/1. mm show a pass rate of 94.3%. Gamma frequency parameters calculation for EBT3 films showed to strongly depend on subtraction of unexposed film pixel values from irradiated ones. In the framework of the described dosimetric procedure, EBT3 films proved to be effective in the verification of high doses delivered to lesions with complex shapes and adjacent to organs at risk.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalMedical Dosimetry
Volume40
Issue number3
DOIs
Publication statusPublished - Feb 3 2015

Fingerprint

Radiosurgery
Radiotherapy
Organs at Risk
Masks
Prescriptions
Brain

Keywords

  • Dosimetric verification
  • Gafchromic EBT3
  • High dose
  • Stereotactic radiosurgery/radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

@article{6ced19b95fbf4ec9814984ad9410a107,
title = "Dosimetric verification of stereotactic radiosurgery/stereotactic radiotherapy dose distributions using Gafchromic EBT3",
abstract = "Aim of this study is to examine the feasibility of using the new Gafchromic EBT3 film in a high-dose stereotactic radiosurgery and radiotherapy quality assurance procedure. Owing to the reduced dimensions of the involved lesions, the feasibility of scanning plan verification films on the scanner plate area with the best uniformity rather than using a correction mask was evaluated. For this purpose, signal values dispersion and reproducibility of film scans were investigated. Uniformity was then quantified in the selected area and was found to be within 1.5{\%} for doses up to 8. Gy. A high-dose threshold level for analyses using this procedure was established evaluating the sensitivity of the irradiated films. Sensitivity was found to be of the order of centiGray for doses up to 6.2. Gy and decreasing for higher doses. The obtained results were used to implement a procedure comparing dose distributions delivered with a CyberKnife system to planned ones. The procedure was validated through single beam irradiation on a Gafchromic film. The agreement between dose distributions was then evaluated for 13 patients (brain lesions, 5. Gy/die prescription isodose ~80{\%}) using gamma analysis. Results obtained using Gamma test criteria of 5{\%}/1. mm show a pass rate of 94.3{\%}. Gamma frequency parameters calculation for EBT3 films showed to strongly depend on subtraction of unexposed film pixel values from irradiated ones. In the framework of the described dosimetric procedure, EBT3 films proved to be effective in the verification of high doses delivered to lesions with complex shapes and adjacent to organs at risk.",
keywords = "Dosimetric verification, Gafchromic EBT3, High dose, Stereotactic radiosurgery/radiotherapy",
author = "Davide Cusumano and Fumagalli, {Maria L.} and Marcello Marchetti and Laura Fariselli and {De Martin}, Elena",
year = "2015",
month = "2",
day = "3",
doi = "10.1016/j.meddos.2015.01.001",
language = "English",
volume = "40",
pages = "226--231",
journal = "Medical Dosimetry",
issn = "0958-3947",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Dosimetric verification of stereotactic radiosurgery/stereotactic radiotherapy dose distributions using Gafchromic EBT3

AU - Cusumano, Davide

AU - Fumagalli, Maria L.

AU - Marchetti, Marcello

AU - Fariselli, Laura

AU - De Martin, Elena

PY - 2015/2/3

Y1 - 2015/2/3

N2 - Aim of this study is to examine the feasibility of using the new Gafchromic EBT3 film in a high-dose stereotactic radiosurgery and radiotherapy quality assurance procedure. Owing to the reduced dimensions of the involved lesions, the feasibility of scanning plan verification films on the scanner plate area with the best uniformity rather than using a correction mask was evaluated. For this purpose, signal values dispersion and reproducibility of film scans were investigated. Uniformity was then quantified in the selected area and was found to be within 1.5% for doses up to 8. Gy. A high-dose threshold level for analyses using this procedure was established evaluating the sensitivity of the irradiated films. Sensitivity was found to be of the order of centiGray for doses up to 6.2. Gy and decreasing for higher doses. The obtained results were used to implement a procedure comparing dose distributions delivered with a CyberKnife system to planned ones. The procedure was validated through single beam irradiation on a Gafchromic film. The agreement between dose distributions was then evaluated for 13 patients (brain lesions, 5. Gy/die prescription isodose ~80%) using gamma analysis. Results obtained using Gamma test criteria of 5%/1. mm show a pass rate of 94.3%. Gamma frequency parameters calculation for EBT3 films showed to strongly depend on subtraction of unexposed film pixel values from irradiated ones. In the framework of the described dosimetric procedure, EBT3 films proved to be effective in the verification of high doses delivered to lesions with complex shapes and adjacent to organs at risk.

AB - Aim of this study is to examine the feasibility of using the new Gafchromic EBT3 film in a high-dose stereotactic radiosurgery and radiotherapy quality assurance procedure. Owing to the reduced dimensions of the involved lesions, the feasibility of scanning plan verification films on the scanner plate area with the best uniformity rather than using a correction mask was evaluated. For this purpose, signal values dispersion and reproducibility of film scans were investigated. Uniformity was then quantified in the selected area and was found to be within 1.5% for doses up to 8. Gy. A high-dose threshold level for analyses using this procedure was established evaluating the sensitivity of the irradiated films. Sensitivity was found to be of the order of centiGray for doses up to 6.2. Gy and decreasing for higher doses. The obtained results were used to implement a procedure comparing dose distributions delivered with a CyberKnife system to planned ones. The procedure was validated through single beam irradiation on a Gafchromic film. The agreement between dose distributions was then evaluated for 13 patients (brain lesions, 5. Gy/die prescription isodose ~80%) using gamma analysis. Results obtained using Gamma test criteria of 5%/1. mm show a pass rate of 94.3%. Gamma frequency parameters calculation for EBT3 films showed to strongly depend on subtraction of unexposed film pixel values from irradiated ones. In the framework of the described dosimetric procedure, EBT3 films proved to be effective in the verification of high doses delivered to lesions with complex shapes and adjacent to organs at risk.

KW - Dosimetric verification

KW - Gafchromic EBT3

KW - High dose

KW - Stereotactic radiosurgery/radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84939469447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939469447&partnerID=8YFLogxK

U2 - 10.1016/j.meddos.2015.01.001

DO - 10.1016/j.meddos.2015.01.001

M3 - Article

C2 - 25680475

AN - SCOPUS:84939469447

VL - 40

SP - 226

EP - 231

JO - Medical Dosimetry

JF - Medical Dosimetry

SN - 0958-3947

IS - 3

ER -