Dosimetry in nuclear medicine therapy: Radiobiology application and results

L. Strigari, M. Benassi, C. Chiesa, M. Cremonesi, L. Bodei, M. D'Andrea

Research output: Contribution to journalArticlepeer-review

Abstract

The linear quadratic model (LQM) has largely been used to assess the radiobiological damage to tissue by external beam fractionated radiotherapy and more recently has been extended to encompass a general continuous time varying dose rate protocol such as targeted radionuclide therapy (TRT). In this review, we provide the basic aspects of radiobiology, from a theoretical point of view, starting from the "four Rs" of radiobiology and introducing the biologically effective doses, which may be used to quantify the impact of a treatment on both tumors and normal tissues. We also present the main parameters required in the LQM, and illustrate the main models of tumor control probability and normal tissue complication probability and summarize the main dose-effect responses, reported in literature, which demonstrate the tentative link between targeted radiotherapy doses and those used in conventional radiotherapy. A better understanding of the radiobiology and mechanisms of action of TRT could contribute to describe the clinical data and guide the development of future compounds and the designing of prospective clinical trials.

Original languageEnglish
Pages (from-to)205-221
Number of pages17
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume55
Issue number2
Publication statusPublished - Apr 2011

Keywords

  • Neoplasms
  • Nuclear medicine
  • Radiobiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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