Dosimetry in peptide radionuclide receptor therapy: A review

Marta Cremonesi, Mahila Ferrari, Lisa Bodei, Giampiero Tosi, Giovanni Paganelli

Research output: Contribution to journalArticlepeer-review

Abstract

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.

Original languageEnglish
Pages (from-to)1467-1475
Number of pages9
JournalJournal of Nuclear Medicine
Volume47
Issue number9
Publication statusPublished - Sep 1 2006

Keywords

  • In
  • Lu
  • Y
  • Dosimetry
  • Peptide receptor radionuclide therapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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