Dosimetry in peptide radionuclide receptor therapy: A review

Marta Cremonesi; Mahila Ferrari; Lisa Bodei; Giampiero Tosi; Giovanni Paganelli

Dosimetry in peptide radionuclide receptor therapy: A review

Marta Cremonesi, Mahila Ferrari, Lisa Bodei, Giampiero Tosi, Giovanni Paganelli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.

Original language	English
Pages (from-to)	1467-1475
Number of pages	9
Journal	Journal of Nuclear Medicine
Volume	47
Issue number	9
Publication status	Published - Sep 1 2006

Keywords

In
Lu
Y
Dosimetry
Peptide receptor radionuclide therapy

ASJC Scopus subject areas

Radiological and Ultrasound Technology

Cite this

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AU - Ferrari, Mahila

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AU - Tosi, Giampiero

AU - Paganelli, Giovanni

PY - 2006/9/1

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AB - The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.

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KW - Y

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Dosimetry in peptide radionuclide receptor therapy: A review

Abstract

Keywords

ASJC Scopus subject areas

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