Dosimetry study in patients with autonomous thyroid nodule who are candidates for radioiodine therapy

Eugenio Reschini, Roberta Matheoud, Cristina Canzi, Massimo Castellani, Marco Galelli, Carlo Ferrari, Alessandra Paracchi, Paolo Gerundini

Research output: Contribution to journalArticlepeer-review

Abstract

A dosimetry study was performed on 26 patients with an autonomous thyroid nodule and suppressed serum thyroid-stimulating hormone, to determine the dose to extranodular tissue when the nodule receives 300 Gy for 131I therapy. Methods: Parameters of radioiodine turnover to be used in the dosimetry formula were separately obtained for the nodule and the contralateral lobe, as a measurable example of the extranodular tissue, using 55 MBq 123I and a computer-assisted gamma camera. The biologic half-life of 123I was then converted into the effective half-life of 131I, and the volumes of the nodule and the lobe were obtained by scintigraphy or sonography. Results: The mean dose to the contralateral lobe from uptake and irradiation by the nodule was calculated to be 32 Gy, and that to the ipsilateral lobe was estimated to be 34 Gy. Conclusion: During radioiodine therapy for autonomous thyroid nodules, the extranodular tissue receives a higher dose than is generally assumed, which explains the relatively high rate of post-treatment hypothyroidism reported in the literature.

Original languageEnglish
Pages (from-to)1928-1934
Number of pages7
JournalJournal of Nuclear Medicine
Volume40
Issue number11
Publication statusPublished - Nov 1999

Keywords

  • Autonomous thyroid nodule
  • Dosimetry study
  • Radioiodine treatment

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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