DOTS-Finder: A comprehensive tool for assessing driver genes in cancer genomes

Giorgio E M Melloni, Alessandro G E Ogier, Stefano de Pretis, Luca Mazzarella, Mattia Pelizzola, Pier G. Pelicci, Laura Riva

Research output: Contribution to journalArticlepeer-review


A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor samples. We have identified driver genes in the genomic data of 34 tumor types derived from existing exploratory projects such as The Cancer Genome Atlas and from studies investigating the usefulness of genomic information in the clinical settings. DOTS-Finder is available at

Original languageEnglish
Article number44
JournalGenome Medicine
Issue number6
Publication statusPublished - Jun 10 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)
  • Genetics


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