Double-biguanide therapy for resistant Acanthamoeba keratitis

Giulio Ferrari, Stanislav Matuska, Paolo Rama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. Methods: Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year-old woman presenting with corneal ulcer in her left eye. Results: The patient was successfully treated with PHMB-chlorhexidine association therapy. Subsequent perforating keratoplasty remained clear at the last follow-up visit after 7 months and increased visual acuity to 20/20 with correction. Conclusions: This case emphasizes the proteiform aspects of Acanthamoeba drug resistance, and suggests that PHMB-chlorhexidine association might represent an additional option for cases resistant to standard therapy.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalCase Reports in Ophthalmology
Volume2
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Acanthamoeba Keratitis
Biguanides
Chlorhexidine
Acanthamoeba
Corneal Ulcer
Corneal Transplantation
Drug Resistance
Visual Acuity
Therapeutics
polyhexamethylene biguanide
hexamidine

Keywords

  • Acanthamoeba keratitis
  • Biguanide
  • Diamidine

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Double-biguanide therapy for resistant Acanthamoeba keratitis. / Ferrari, Giulio; Matuska, Stanislav; Rama, Paolo.

In: Case Reports in Ophthalmology, Vol. 2, No. 3, 09.2011, p. 338-342.

Research output: Contribution to journalArticle

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