Double-blind comparison of the cardioselective β-blockers bisoprolol and atenolol in hypertension

The bisoprolol international multicenter study (BIMS)

Fritz R. Bühler, G. Berglund, O. K. Anderson, H. R. Brunner, U. Scherrer, P. van Brummelen, A. Distler, Th Philipp, R. Fogari, A. Mimran, J. Fourcade, C. Dal Palù, B. N C Prichard, C. I. Backhouse, J. L. Reid, L. Elliott, A. Zanchetti

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The antihypertensive efficacy and tolerability of bisoprolol and atenolol were compared in the Bisoprolol International Multicenter Study (BIMS). In 104 patients with essential hypertension (21 to 70 years of age and diastolic blood pressures (DBP) of 100-120 mm Hg in the sitting position), after a four-week placebo period, the active drug was given in a random double-blind crossover design (10 to 20 mg bisoprolol, 50 to 100 mg atenolol) for eight weeks each, with a 2 to 6 week placebo wash-out phase between active therapy. All blood pressures were recorded 24 h after drug intake. Of the 104 patients, 10 were withdrawn during the study because of unwanted effects, unsatisfactory blood pressure response, or intercurrent disease, leaving 94 for intraindividual comparisons. After 8 weeks active treatment with individually titrated dose, there were slightly, but significantly greater falls in blood pressure with bisoprolol (p ≤ 0.05). Diastolic target pressures of ≦95 mm Hg were reached in 68% with bisoprolol and 56% with atenolol (p ≤ 0.05; Mc Nemar). There was no between treatment group difference in the patients' self-assessed well-being. For both drugs, response rates were greater in patients below the age of 60 years than in those above 60 years. Better antihypertensive responses were observed with bisoprolol in patients regularly smoking cigarettes.

Original languageEnglish
Pages (from-to)S122-S127
JournalJournal of Cardiovascular Pharmacology
Volume8
Publication statusPublished - 1986

Fingerprint

Bisoprolol
Atenolol
Multicenter Studies
Blood Pressure
Hypertension
Antihypertensive Agents
Placebos
Pharmaceutical Preparations
Posture
Cross-Over Studies
Therapeutics
Smoking

Keywords

  • Atenolol
  • Bisoprolol
  • Hypertension
  • Multicenter study
  • Response rates
  • Smoking
  • β-Blockers

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Bühler, F. R., Berglund, G., Anderson, O. K., Brunner, H. R., Scherrer, U., van Brummelen, P., ... Zanchetti, A. (1986). Double-blind comparison of the cardioselective β-blockers bisoprolol and atenolol in hypertension: The bisoprolol international multicenter study (BIMS). Journal of Cardiovascular Pharmacology, 8, S122-S127.

Double-blind comparison of the cardioselective β-blockers bisoprolol and atenolol in hypertension : The bisoprolol international multicenter study (BIMS). / Bühler, Fritz R.; Berglund, G.; Anderson, O. K.; Brunner, H. R.; Scherrer, U.; van Brummelen, P.; Distler, A.; Philipp, Th; Fogari, R.; Mimran, A.; Fourcade, J.; Dal Palù, C.; Prichard, B. N C; Backhouse, C. I.; Reid, J. L.; Elliott, L.; Zanchetti, A.

In: Journal of Cardiovascular Pharmacology, Vol. 8, 1986, p. S122-S127.

Research output: Contribution to journalArticle

Bühler, FR, Berglund, G, Anderson, OK, Brunner, HR, Scherrer, U, van Brummelen, P, Distler, A, Philipp, T, Fogari, R, Mimran, A, Fourcade, J, Dal Palù, C, Prichard, BNC, Backhouse, CI, Reid, JL, Elliott, L & Zanchetti, A 1986, 'Double-blind comparison of the cardioselective β-blockers bisoprolol and atenolol in hypertension: The bisoprolol international multicenter study (BIMS)', Journal of Cardiovascular Pharmacology, vol. 8, pp. S122-S127.
Bühler, Fritz R. ; Berglund, G. ; Anderson, O. K. ; Brunner, H. R. ; Scherrer, U. ; van Brummelen, P. ; Distler, A. ; Philipp, Th ; Fogari, R. ; Mimran, A. ; Fourcade, J. ; Dal Palù, C. ; Prichard, B. N C ; Backhouse, C. I. ; Reid, J. L. ; Elliott, L. ; Zanchetti, A. / Double-blind comparison of the cardioselective β-blockers bisoprolol and atenolol in hypertension : The bisoprolol international multicenter study (BIMS). In: Journal of Cardiovascular Pharmacology. 1986 ; Vol. 8. pp. S122-S127.
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AU - van Brummelen, P.

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AU - Backhouse, C. I.

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AU - Elliott, L.

AU - Zanchetti, A.

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