Étude contrólée en double insu de I'acide ursodeoxycholique (UDCA) versus placebo dans le traitement de la gastrite par reflux chez des patients non opérés

Translated title of the contribution: Double-blind controlled trial of ursodeoxycholic acid (UDCA) versus placebo in the treatment of reflux gastritis in patients not submitted to gastric surgery

E. Masci, P. A. Testoni, M. Guslandi, L. Fanti, A. Pellegrini, G. Ronchi, A. Tittobello

Research output: Contribution to journalArticlepeer-review

Abstract

Bile acids have been incriminated in the pathogenesis of reflux gastritis, also in patients not submitted to gastric surgery. Their damaging effect on the gastric mucosa is different, UDCA being less noxious than other bile acids. Thirty patients with superficial alkaline reflux gastritis were randomly treated with ursodeoxycholic acid (UDCA) (150 mg b.i.d.) or placebo for 12 weeks in a double-blind controlled trial. Total bile acids in the gastric samples were measured to confirm duodenogastric reflux. The severity of dyspeptic symptoms and the grade of endoscopic and histological gastritis were assessed before treatment and at the end of the study. No differences were found between UDCA and placebo as for their effects on symptoms, endoscopic and histological features. However a statistically significant effect of both UDCA and placebo was found when clinical reports at 6 and 12 weeks and endoscopic and histological features at 12 weeks were compared with the corresponding pre-treatment findings. The considerable " placebo effect " observed in our study makes the results inconclusive. Whether UDCA would be beneficial in the treatment of reflux gastritis in patients not submitted to gastric surgery needs further evaluation in larger series of subjects.

Translated title of the contributionDouble-blind controlled trial of ursodeoxycholic acid (UDCA) versus placebo in the treatment of reflux gastritis in patients not submitted to gastric surgery
Original languageGerman
Pages (from-to)251-260
Number of pages10
JournalActa Endoscopica
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 1989

Keywords

  • endoscopy
  • histology
  • reflux gastritis
  • symptoms
  • UDCA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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