Double-blind study of oral γ-vinyl GABA in the treatment of dystonia

F. Carella, F. Girotti, G. Scigliano, T. Caraceni, A. M. Joder-Ohlenbusch, P. J. Schechter

Research output: Contribution to journalArticlepeer-review

Abstract

Six patients with different forms of dystonia were treated with γ-vinyl GABA, a specific enzyme-activated inhibitor of GABA-trans-aminase, in a double-blind, placebo-controlled crossover study, γ-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalNeurology
Volume36
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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