Double nerve intraneural interface implant on a human amputee for robotic hand control

Paolo M. Rossini, Silvestro Micera, Antonella Benvenuto, Jacopo Carpaneto, Giuseppe Cavallo, Luca Citi, Christian Cipriani, Luca Denaro, Vincenzo Denaro, Giovanni Di Pino, Florinda Ferreri, Eugenio Guglielmelli, Klaus Peter Hoffmann, Stanisa Raspopovic, Jacopo Rigosa, Luca Rossini, Mario Tombini, Paolo Dario

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Objectives: The principle underlying this project is that, despite nervous reorganization following upper limb amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses. Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data. Methods: Four intrafascicular longitudinal flexible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order. Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached >85% real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantom-limb syndrome (PLS). Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit. Significance: This study represents a breakthrough in robotic hand use in amputees.

Original languageEnglish
Pages (from-to)777-783
Number of pages7
JournalClinical Neurophysiology
Volume121
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

Amputees
Robotics
Phantom Limb
Hand
Artificial Intelligence
Prostheses and Implants
Ulnar Nerve
Median Nerve
Amputation
Upper Extremity
Fingers
Therapeutics

Keywords

  • Hand prosthesis
  • Intraneural interface
  • Limb amputation
  • Neural plasticity
  • Phantom-limb syndrome
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Double nerve intraneural interface implant on a human amputee for robotic hand control. / Rossini, Paolo M.; Micera, Silvestro; Benvenuto, Antonella; Carpaneto, Jacopo; Cavallo, Giuseppe; Citi, Luca; Cipriani, Christian; Denaro, Luca; Denaro, Vincenzo; Di Pino, Giovanni; Ferreri, Florinda; Guglielmelli, Eugenio; Hoffmann, Klaus Peter; Raspopovic, Stanisa; Rigosa, Jacopo; Rossini, Luca; Tombini, Mario; Dario, Paolo.

In: Clinical Neurophysiology, Vol. 121, No. 5, 05.2010, p. 777-783.

Research output: Contribution to journalArticle

Rossini, PM, Micera, S, Benvenuto, A, Carpaneto, J, Cavallo, G, Citi, L, Cipriani, C, Denaro, L, Denaro, V, Di Pino, G, Ferreri, F, Guglielmelli, E, Hoffmann, KP, Raspopovic, S, Rigosa, J, Rossini, L, Tombini, M & Dario, P 2010, 'Double nerve intraneural interface implant on a human amputee for robotic hand control', Clinical Neurophysiology, vol. 121, no. 5, pp. 777-783. https://doi.org/10.1016/j.clinph.2010.01.001
Rossini, Paolo M. ; Micera, Silvestro ; Benvenuto, Antonella ; Carpaneto, Jacopo ; Cavallo, Giuseppe ; Citi, Luca ; Cipriani, Christian ; Denaro, Luca ; Denaro, Vincenzo ; Di Pino, Giovanni ; Ferreri, Florinda ; Guglielmelli, Eugenio ; Hoffmann, Klaus Peter ; Raspopovic, Stanisa ; Rigosa, Jacopo ; Rossini, Luca ; Tombini, Mario ; Dario, Paolo. / Double nerve intraneural interface implant on a human amputee for robotic hand control. In: Clinical Neurophysiology. 2010 ; Vol. 121, No. 5. pp. 777-783.
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abstract = "Objectives: The principle underlying this project is that, despite nervous reorganization following upper limb amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses. Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data. Methods: Four intrafascicular longitudinal flexible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order. Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached >85{\%} real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantom-limb syndrome (PLS). Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit. Significance: This study represents a breakthrough in robotic hand use in amputees.",
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AU - Micera, Silvestro

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AU - Carpaneto, Jacopo

AU - Cavallo, Giuseppe

AU - Citi, Luca

AU - Cipriani, Christian

AU - Denaro, Luca

AU - Denaro, Vincenzo

AU - Di Pino, Giovanni

AU - Ferreri, Florinda

AU - Guglielmelli, Eugenio

AU - Hoffmann, Klaus Peter

AU - Raspopovic, Stanisa

AU - Rigosa, Jacopo

AU - Rossini, Luca

AU - Tombini, Mario

AU - Dario, Paolo

PY - 2010/5

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N2 - Objectives: The principle underlying this project is that, despite nervous reorganization following upper limb amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses. Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data. Methods: Four intrafascicular longitudinal flexible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order. Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached >85% real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantom-limb syndrome (PLS). Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit. Significance: This study represents a breakthrough in robotic hand use in amputees.

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KW - Intraneural interface

KW - Limb amputation

KW - Neural plasticity

KW - Phantom-limb syndrome

KW - Transcranial magnetic stimulation

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