Double–blind trial ru 41740 vs. Placebo: Immunological and clinical effects in a group of patients with chronic bronchitis

A. Fietta, C. Bersani, V. De Rose, P. Mangiarotti, C. Merlini, M. Uccelli, G. Guidi, Gialdroni Grassi

Research output: Contribution to journalArticlepeer-review

Abstract

A double-blind trial was performed to investigate the effects of RU 41740, a glycoprotein extract from Klebsiella pneumoniae, on host defenses and its efficacy in reducing the number of exacerbations in 29 evaluable patients with chronic bronchitis, out of 36 patients who entered the study. The drug enhanced the phagocytosis indexes of both polymorphonuclear and mononuclear phagocytes. Increased candidacidal activity of monocytes was also observed. These effects, already detectable after one course of therapy and during the entire period of treatment, were no longer detectable when tested 6 months after the end of treatment. A significantly (p <0.05) larger number of patients in the treated group than in the placebo group had no exacerbations during drug administration (0−3 months). Moreover, patients treated with RU 41740 had significantly fewer and shorter episodes of acute exacerbation. The positive decreases in these two parameters persisted throughout the follow-up.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalRespiration
Volume54
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Chronic bronchitis
  • Clinical efficacy
  • Monocytes
  • Neutrophils
  • RU 41740

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

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