TY - JOUR
T1 - Down patients
T2 - Extracellular preamyloid deposits precede neuritic degeneration and senile plaques
AU - Giaccone, Giorgio
AU - Tagliavini, Fabrizio
AU - Linoli, Giovanni
AU - Bouras, Constantin
AU - Frigerio, Luciano
AU - Frangione, Blas
AU - Bugiani, Orso
PY - 1989/2/13
Y1 - 1989/2/13
N2 - Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of the Alzheimer amyloid β-protein) to investigate the cerebral cortex of 6 Down patients aged 6-55 y, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled. These deposits were similar to the extracellular deposits previously observed in the cerebral cortex of Alzheimer patients and non-demented individuals. The material accumulated in the deposits did not react with Congo red, thioflavine S or, on some occasions, silver salts and therefore might have been constituted by β-protein precursors lacking the molecular conformation of amyloid fibrils. Age-related analysis of the cortical lesions in Down patients suggested that such extracellular deposits precede degenerating neurites and evolve into senile plaques.
AB - Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of the Alzheimer amyloid β-protein) to investigate the cerebral cortex of 6 Down patients aged 6-55 y, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled. These deposits were similar to the extracellular deposits previously observed in the cerebral cortex of Alzheimer patients and non-demented individuals. The material accumulated in the deposits did not react with Congo red, thioflavine S or, on some occasions, silver salts and therefore might have been constituted by β-protein precursors lacking the molecular conformation of amyloid fibrils. Age-related analysis of the cortical lesions in Down patients suggested that such extracellular deposits precede degenerating neurites and evolve into senile plaques.
KW - Alzheimer's disease
KW - Amyloid
KW - Down's syndrome
KW - Immunocytochemistry
KW - Senile plaque
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U2 - 10.1016/0304-3940(89)90169-9
DO - 10.1016/0304-3940(89)90169-9
M3 - Article
C2 - 2521927
AN - SCOPUS:0024496624
VL - 97
SP - 232
EP - 238
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -