Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

Giorgio Giaccone, Fabrizio Tagliavini, Giovanni Linoli, Constantin Bouras, Luciano Frigerio, Blas Frangione, Orso Bugiani

Research output: Contribution to journalArticle

Abstract

Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of the Alzheimer amyloid β-protein) to investigate the cerebral cortex of 6 Down patients aged 6-55 y, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled. These deposits were similar to the extracellular deposits previously observed in the cerebral cortex of Alzheimer patients and non-demented individuals. The material accumulated in the deposits did not react with Congo red, thioflavine S or, on some occasions, silver salts and therefore might have been constituted by β-protein precursors lacking the molecular conformation of amyloid fibrils. Age-related analysis of the cortical lesions in Down patients suggested that such extracellular deposits precede degenerating neurites and evolve into senile plaques.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalNeuroscience Letters
Volume97
Issue number1-2
DOIs
Publication statusPublished - Feb 13 1989

Keywords

  • Alzheimer's disease
  • Amyloid
  • Down's syndrome
  • Immunocytochemistry
  • Senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)

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