Down-regulation of ζ chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma

Lorenzo Pignataro, Daude Pagani, Bruno Brando, Giuseppe Sambataro, Barbara Scarpati, Massimiliano M. Corsi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To evaluate ζ chain and Zap 70 expression in T lymphocytes of patients with laryngeal cancer in relation to surgical treatment. STUDY DESIGN: This study investigated, by dual-color flow cytometry, ζ chain and Zap 70 expression in the circulating T lymphocytes of 13 patients with laryngeal cancer patients before and after surgical treatment. RESULTS: Patients exhibited a significant lower expression of both ζ chain and Zap 70 compared to healthy normal controls; no statistical differences were observed after surgical treatment. CONCLUSION: The results of this investigation seem to indicate that both the ζ chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery. Flow cytometry analysis may represent an easy-to-use procedure for monitoring the immune status of patients with laryngeal cancer.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Volume29
Issue number1
Publication statusPublished - Feb 2007

Keywords

  • ζ chain, zeta-associated protein 70
  • Flow cytometry
  • Lymphocytes
  • Squamous cell carcinoma, laryngeal

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology

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