Abstract
OBJECTIVE: To evaluate ζ chain and Zap 70 expression in T lymphocytes of patients with laryngeal cancer in relation to surgical treatment. STUDY DESIGN: This study investigated, by dual-color flow cytometry, ζ chain and Zap 70 expression in the circulating T lymphocytes of 13 patients with laryngeal cancer patients before and after surgical treatment. RESULTS: Patients exhibited a significant lower expression of both ζ chain and Zap 70 compared to healthy normal controls; no statistical differences were observed after surgical treatment. CONCLUSION: The results of this investigation seem to indicate that both the ζ chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery. Flow cytometry analysis may represent an easy-to-use procedure for monitoring the immune status of patients with laryngeal cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | Analytical and Quantitative Cytology and Histology |
| Volume | 29 |
| Issue number | 1 |
| Publication status | Published - Feb 2007 |
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Keywords
- ζ chain, zeta-associated protein 70
- Flow cytometry
- Lymphocytes
- Squamous cell carcinoma, laryngeal
ASJC Scopus subject areas
- Cell Biology
- Anatomy
- Histology
Cite this
Down-regulation of ζ chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma. / Pignataro, Lorenzo; Pagani, Daude; Brando, Bruno; Sambataro, Giuseppe; Scarpati, Barbara; Corsi, Massimiliano M.
In: Analytical and Quantitative Cytology and Histology, Vol. 29, No. 1, 02.2007, p. 57-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Down-regulation of ζ chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma
AU - Pignataro, Lorenzo
AU - Pagani, Daude
AU - Brando, Bruno
AU - Sambataro, Giuseppe
AU - Scarpati, Barbara
AU - Corsi, Massimiliano M.
PY - 2007/2
Y1 - 2007/2
N2 - OBJECTIVE: To evaluate ζ chain and Zap 70 expression in T lymphocytes of patients with laryngeal cancer in relation to surgical treatment. STUDY DESIGN: This study investigated, by dual-color flow cytometry, ζ chain and Zap 70 expression in the circulating T lymphocytes of 13 patients with laryngeal cancer patients before and after surgical treatment. RESULTS: Patients exhibited a significant lower expression of both ζ chain and Zap 70 compared to healthy normal controls; no statistical differences were observed after surgical treatment. CONCLUSION: The results of this investigation seem to indicate that both the ζ chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery. Flow cytometry analysis may represent an easy-to-use procedure for monitoring the immune status of patients with laryngeal cancer.
AB - OBJECTIVE: To evaluate ζ chain and Zap 70 expression in T lymphocytes of patients with laryngeal cancer in relation to surgical treatment. STUDY DESIGN: This study investigated, by dual-color flow cytometry, ζ chain and Zap 70 expression in the circulating T lymphocytes of 13 patients with laryngeal cancer patients before and after surgical treatment. RESULTS: Patients exhibited a significant lower expression of both ζ chain and Zap 70 compared to healthy normal controls; no statistical differences were observed after surgical treatment. CONCLUSION: The results of this investigation seem to indicate that both the ζ chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery. Flow cytometry analysis may represent an easy-to-use procedure for monitoring the immune status of patients with laryngeal cancer.
KW - ζ chain, zeta-associated protein 70
KW - Flow cytometry
KW - Lymphocytes
KW - Squamous cell carcinoma, laryngeal
UR - http://www.scopus.com/inward/record.url?scp=33847356574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847356574&partnerID=8YFLogxK
M3 - Article
C2 - 17375875
AN - SCOPUS:33847356574
VL - 29
SP - 57
EP - 62
JO - Analytical and Quantitative Cytology
JF - Analytical and Quantitative Cytology
SN - 0884-6812
IS - 1
ER -