Abstract
Changes in the regulation of endocannabinoid production, together with an altered expression of their receptors are hallmarks of cancer, including colorectal cancer (CRC). Although several studies have been conducted to understand the biological role of the CB1 receptor in cancer, little is known about its involvement in the metastatic process of CRC. The aim of this study was to investigate the possible link between CB1 receptor expression and the presence of metastasis in patients with CRC, investigating the main signaling pathways elicited downstream of CB1 receptor in colon cancer. Fifty-nine consecutive patients, with histologically proven colorectal cancer, were enrolled in the study, of which 30 patients with synchronous metastasis, at first diagnosis and 29 without metastasis. A low expression of CB1 receptor were detected in primary tumor tissue of CRC patients with metastasis and consequently, we observed an alteration of CB1 receptor downstream signaling. These signaling routes were also altered in intestinal normal mucosa, suggesting that, normal mucosa surrounding the tumor provides a realistic picture of the molecules involved in tissue malignant transformation. These observations contribute to the idea that drugs able to induce CB1 receptor expression can be helpful in order to set new anticancer therapeutic strategies.
| Original language | English |
|---|---|
| Article number | 708 |
| Journal | Cancers |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2019 |
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Keywords
- Cannabinoid type 1 (CB1) receptor
- Colorectal cancer
- Endocannabinoid system
- Metastasis
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Down-regulation of cannabinoid type 1 (CB1) receptor and its downstream signaling pathways in metastatic colorectal cancer. / Tutino, Valeria; Caruso, Maria Gabriella; De Nunzio, Valentina; Lorusso, Dionigi; Veronese, Nicola; Gigante, Isabella; Notarnicola, Maria; Giannelli, Gianluigi.
In: Cancers, Vol. 11, No. 5, 708, 05.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Down-regulation of cannabinoid type 1 (CB1) receptor and its downstream signaling pathways in metastatic colorectal cancer
AU - Tutino, Valeria
AU - Caruso, Maria Gabriella
AU - De Nunzio, Valentina
AU - Lorusso, Dionigi
AU - Veronese, Nicola
AU - Gigante, Isabella
AU - Notarnicola, Maria
AU - Giannelli, Gianluigi
PY - 2019/5
Y1 - 2019/5
N2 - Changes in the regulation of endocannabinoid production, together with an altered expression of their receptors are hallmarks of cancer, including colorectal cancer (CRC). Although several studies have been conducted to understand the biological role of the CB1 receptor in cancer, little is known about its involvement in the metastatic process of CRC. The aim of this study was to investigate the possible link between CB1 receptor expression and the presence of metastasis in patients with CRC, investigating the main signaling pathways elicited downstream of CB1 receptor in colon cancer. Fifty-nine consecutive patients, with histologically proven colorectal cancer, were enrolled in the study, of which 30 patients with synchronous metastasis, at first diagnosis and 29 without metastasis. A low expression of CB1 receptor were detected in primary tumor tissue of CRC patients with metastasis and consequently, we observed an alteration of CB1 receptor downstream signaling. These signaling routes were also altered in intestinal normal mucosa, suggesting that, normal mucosa surrounding the tumor provides a realistic picture of the molecules involved in tissue malignant transformation. These observations contribute to the idea that drugs able to induce CB1 receptor expression can be helpful in order to set new anticancer therapeutic strategies.
AB - Changes in the regulation of endocannabinoid production, together with an altered expression of their receptors are hallmarks of cancer, including colorectal cancer (CRC). Although several studies have been conducted to understand the biological role of the CB1 receptor in cancer, little is known about its involvement in the metastatic process of CRC. The aim of this study was to investigate the possible link between CB1 receptor expression and the presence of metastasis in patients with CRC, investigating the main signaling pathways elicited downstream of CB1 receptor in colon cancer. Fifty-nine consecutive patients, with histologically proven colorectal cancer, were enrolled in the study, of which 30 patients with synchronous metastasis, at first diagnosis and 29 without metastasis. A low expression of CB1 receptor were detected in primary tumor tissue of CRC patients with metastasis and consequently, we observed an alteration of CB1 receptor downstream signaling. These signaling routes were also altered in intestinal normal mucosa, suggesting that, normal mucosa surrounding the tumor provides a realistic picture of the molecules involved in tissue malignant transformation. These observations contribute to the idea that drugs able to induce CB1 receptor expression can be helpful in order to set new anticancer therapeutic strategies.
KW - Cannabinoid type 1 (CB1) receptor
KW - Colorectal cancer
KW - Endocannabinoid system
KW - Metastasis
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U2 - 10.3390/cancers11050708
DO - 10.3390/cancers11050708
M3 - Article
AN - SCOPUS:85067209107
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 5
M1 - 708
ER -