Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2

Maurizio Giannì, Eliezer Kopf, Julie Bastien, Mustapha Oulad-Abdelghani, Enrico Garattini, Pierre Chambon, Cécile Rochette-Egly

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear retinoic acid (RA) receptors (RARs) are phosphorylated at conserved serine residues located in their N-terminal domain. Phosphorylation of RARγ2 at these residues is increased in response to RA subsequently to the activation of p38MAPK. We show here that this RA-induced phosphorylation of RARγ2 resulted from the down-regulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. By overexpressing Akt and by using agents that activated or inhibited the PI3K/Akt pathway, we also demonstrated that the RA-induced down-regulation of the PI3K/Akt pathway targeted not only the phosphorylation of RARγ2 but also the turnover and transcriptional activity of the receptor. Altogether these data indicate that the PI3K/Akt pathway plays an important role in retinoic acid signaling.

Original languageEnglish
Pages (from-to)24859-24862
Number of pages4
JournalJournal of Biological Chemistry
Volume277
Issue number28
DOIs
Publication statusPublished - Jul 12 2002

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2'. Together they form a unique fingerprint.

Cite this