Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

INMI COVID-19 Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19 in this population. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well as in other most vulnerable patients, in order to improve their management and treatment and to encourage vaccinating these individuals early, once a vaccination is available.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume103
DOIs
Publication statusE-pub ahead of print - Nov 30 2020

Keywords

  • COVID-19 pneumonia
  • Down syndrome
  • Immune activation
  • Immune dysregulation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome'. Together they form a unique fingerprint.

Cite this