Downexpression of aldehyde dehydrogenase 1 in murine lung tumors

Tommaso A. Dragani, F. Stefania Falvella, Giacomo Manenti, Marco A. Pierotti, Romolo A. Gambetta

Research output: Contribution to journalArticle

Abstract

We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldh1 was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldh1 in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalMolecular Carcinogenesis
Volume16
Issue number3
DOIs
Publication statusPublished - 1996

Fingerprint

Lung
Neoplasms
Aldehyde Dehydrogenase
Northern Blotting
Antineoplastic Agents
aldehyde dehydrogenase 1
Pharmaceutical Preparations
Genes

Keywords

  • Disease models
  • disease susceptibility
  • immunohistochemistry
  • inbred strains
  • mice

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

Cite this

Downexpression of aldehyde dehydrogenase 1 in murine lung tumors. / Dragani, Tommaso A.; Falvella, F. Stefania; Manenti, Giacomo; Pierotti, Marco A.; Gambetta, Romolo A.

In: Molecular Carcinogenesis, Vol. 16, No. 3, 1996, p. 123-125.

Research output: Contribution to journalArticle

Dragani, Tommaso A. ; Falvella, F. Stefania ; Manenti, Giacomo ; Pierotti, Marco A. ; Gambetta, Romolo A. / Downexpression of aldehyde dehydrogenase 1 in murine lung tumors. In: Molecular Carcinogenesis. 1996 ; Vol. 16, No. 3. pp. 123-125.
@article{c1727ef73156460f97256e4f860776a8,
title = "Downexpression of aldehyde dehydrogenase 1 in murine lung tumors",
abstract = "We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldh1 was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldh1 in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.",
keywords = "Disease models, disease susceptibility, immunohistochemistry, inbred strains, mice",
author = "Dragani, {Tommaso A.} and Falvella, {F. Stefania} and Giacomo Manenti and Pierotti, {Marco A.} and Gambetta, {Romolo A.}",
year = "1996",
doi = "10.1002/(SICI)1098-2744(199607)16:3<123::AID-MC1>3.0.CO;2-I",
language = "English",
volume = "16",
pages = "123--125",
journal = "Molecular Carcinogenesis",
issn = "0899-1987",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Downexpression of aldehyde dehydrogenase 1 in murine lung tumors

AU - Dragani, Tommaso A.

AU - Falvella, F. Stefania

AU - Manenti, Giacomo

AU - Pierotti, Marco A.

AU - Gambetta, Romolo A.

PY - 1996

Y1 - 1996

N2 - We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldh1 was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldh1 in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.

AB - We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldh1 was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldh1 in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.

KW - Disease models

KW - disease susceptibility

KW - immunohistochemistry

KW - inbred strains

KW - mice

UR - http://www.scopus.com/inward/record.url?scp=0029774062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029774062&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-2744(199607)16:3<123::AID-MC1>3.0.CO;2-I

DO - 10.1002/(SICI)1098-2744(199607)16:3<123::AID-MC1>3.0.CO;2-I

M3 - Article

C2 - 8688146

AN - SCOPUS:0029774062

VL - 16

SP - 123

EP - 125

JO - Molecular Carcinogenesis

JF - Molecular Carcinogenesis

SN - 0899-1987

IS - 3

ER -