Downexpression of aldehyde dehydrogenase 1 in murine lung tumors

Tommaso A. Dragani, F. Stefania Falvella, Giacomo Manenti, Marco A. Pierotti, Romolo A. Gambetta

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldh1 was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldh1 in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalMolecular Carcinogenesis
Volume16
Issue number3
DOIs
Publication statusPublished - 1996

Keywords

  • Disease models
  • disease susceptibility
  • immunohistochemistry
  • inbred strains
  • mice

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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