TY - JOUR
T1 - Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects
T2 - Toward qualitative rather than quantitative assays
AU - Cagigi, Alberto
AU - Cotugno, Nicola
AU - Rinaldi, Stefano
AU - Santilli, Veronica
AU - Rossi, Paolo
AU - Palma, Paolo
PY - 2015
Y1 - 2015
N2 - Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.
AB - Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.
KW - Antibody vs. memory B-cell responses
KW - Long-lasting immunologic memory
KW - Repeated immunization
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U2 - 10.1111/pai.12483
DO - 10.1111/pai.12483
M3 - Article
AN - SCOPUS:84951325691
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
SN - 0905-6157
ER -