Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects: Toward qualitative rather than quantitative assays

Alberto Cagigi, Nicola Cotugno, Stefano Rinaldi, Veronica Santilli, Paolo Rossi, Paolo Palma

Research output: Contribution to journalArticlepeer-review

Abstract

Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.

Original languageEnglish
JournalPediatric Allergy and Immunology
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Antibody vs. memory B-cell responses
  • Long-lasting immunologic memory
  • Repeated immunization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Fingerprint Dive into the research topics of 'Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects: Toward qualitative rather than quantitative assays'. Together they form a unique fingerprint.

Cite this