Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways

Patrizia Pignatti, Gianna Moscato, Simona Casarini, Monica Delmastro, Mariangela Poppa, Giuseppe Brunetti, Paolo Pisati, Bruno Balbi

Research output: Contribution to journalArticle

Abstract

CXCL8/IL-8 is the most significant chemokine for neutrophils, and CXC chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by CXCL8/IL-8 and endotoxin on activated neutrophils. We sought to evaluate the expression of the CXCL8/IL-8 receptors and the activation marker CD11b on neutrophils in peripheral blood and in the site of airway inflammation. The flow cytometric expression of CXCR1, CXCR2, and CD11b was evaluated on peripheral blood and induced sputum neutrophils in patients with nonsevere asthma with greater than 60% sputum neutrophils, in patients with chronic obstructive pulmonary disease (COPD), and in healthy control subjects. Asthmatic patients and patients with COPD had comparable expressions of CXCR1, CXCR2, and CD11b on peripheral blood and sputum neutrophils. Compared with control subjects, the peripheral neutrophil expression of CXCR2 was lower in patients with COPD (P =. 03) and that of CD11b was higher in asthmatic patients and patients with COPD (P

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Asthma
  • chronic obstructive pulmonary disease
  • CXC chemokine receptor 1
  • CXC chemokine receptor 2
  • CXCL8/IL-8
  • neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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