Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

Paula Müssnich; Gerald Raverot; Marie Lise Jaffrain-Rea; Filippo Fraggetta; Anne Wierinckx; Jacqueline Trouillas; Alfredo Fusco; Daniela D'Angelo

doi:10.1080/15384101.2015.1064207

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

Paula Müssnich, Gerald Raverot, Marie Lise Jaffrain-Rea, Filippo Fraggetta, Anne Wierinckx, Jacqueline Trouillas, Alfredo Fusco, Daniela D'Angelo

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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

Original language	English
Pages (from-to)	2590-2597
Number of pages	8
Journal	Cell Cycle
Volume	14
Issue number	16
DOIs	https://doi.org/10.1080/15384101.2015.1064207
Publication status	Published - Jan 1 2015

Keywords

Cyclin B1
miRNA-410
Pituitary adenomas

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Developmental Biology

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10.1080/15384101.2015.1064207

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title = "Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors",

abstract = "MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.",

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T1 - Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

AU - Müssnich, Paula

AU - Raverot, Gerald

AU - Jaffrain-Rea, Marie Lise

AU - Fraggetta, Filippo

AU - Wierinckx, Anne

AU - Trouillas, Jacqueline

AU - Fusco, Alfredo

AU - D'Angelo, Daniela

PY - 2015/1/1

Y1 - 2015/1/1

N2 - MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

AB - MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

KW - Cyclin B1

KW - miRNA-410

KW - Pituitary adenomas

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Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

Abstract

Keywords

ASJC Scopus subject areas

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