DAS DOWN-SYNDROM ALS IMMUNMANGEL-MODELL. ERGEBNISSE UND HYPOTHESEN

Translated title of the contribution: Down's syndrome as a model of immunodeficiency. Facts and speculations

G. R. Burgio, A. G. Ugazio

Research output: Contribution to journalArticle

Abstract

In Down's syndrome the great numbers of errors in the formation of DNA may be the real pathogenetic factors for the immunodeficiency and the generally accelerated advance of age. It would not be a matter of wonder if a disorder of the somatic repetition of genetic information should involve in particular those cells which, like the immunocytes, rapidly multiply during the whole of life. According to these notions the Down's syndrome can be envisaged as a model for the study of the relationships between immunodeficiency, aging and the outbreak of malignomas and autoimmune diseases. Because of its frequency it is more accessible and more easily controllable than other more classical experiments of nature in the domain of immunodeficiency state, as, for instance, thymus aplasia or congenital agammaglobulinemia.

Translated title of the contributionDown's syndrome as a model of immunodeficiency. Facts and speculations
Original languageGerman
Pages (from-to)5-9
Number of pages5
JournalHelvetica Paediatrica Acta
Volume33
Issue number1
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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