In Down's syndrome the great numbers of errors in the formation of DNA may be the real pathogenetic factors for the immunodeficiency and the generally accelerated advance of age. It would not be a matter of wonder if a disorder of the somatic repetition of genetic information should involve in particular those cells which, like the immunocytes, rapidly multiply during the whole of life. According to these notions the Down's syndrome can be envisaged as a model for the study of the relationships between immunodeficiency, aging and the outbreak of malignomas and autoimmune diseases. Because of its frequency it is more accessible and more easily controllable than other more classical experiments of nature in the domain of immunodeficiency state, as, for instance, thymus aplasia or congenital agammaglobulinemia.
|Translated title of the contribution||Down's syndrome as a model of immunodeficiency. Facts and speculations|
|Number of pages||5|
|Journal||Helvetica Paediatrica Acta|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health