TY - JOUR
T1 - Dramatic regression of multiple brain metastases from breast cancer with Capecitabine
T2 - Another arrow at the bow?
AU - Fabi, A.
AU - Vidiri, A.
AU - Ferretti, G.
AU - Felici, A.
AU - Papaldo, P.
AU - Carlini, P.
AU - Mirri, A.
AU - Nuzzo, C.
AU - Cognetti, F.
PY - 2006/6
Y1 - 2006/6
N2 - Several chemotherapic agents, which are active againstbreast cancer, penetrate poorly into the central nervous system. Despite its limited brain penetration, 5-fluorouracil has been a component of effective regimens for brain metastases. Capecitabine is a recently developed oral prodrug that is converted into 5-fluorouracil by sequential enzymatic steps. Thymidine phosphorylase (TP) is the final enzyme responsible for Capecitabine activation. Studies have demonstrated that high intratumoral levels of TP and low levels of its catabolite dihydropyrimidine-dehydrogenase are correlated with the capecitabine response. The penetration of Capecitabine across the brain-blood barrier remains unknown; we report the case of and discuss a breast cancer patient who had an interesting response of brain metastases with Capecitabine in monochemotherapy before brain irradiation.
AB - Several chemotherapic agents, which are active againstbreast cancer, penetrate poorly into the central nervous system. Despite its limited brain penetration, 5-fluorouracil has been a component of effective regimens for brain metastases. Capecitabine is a recently developed oral prodrug that is converted into 5-fluorouracil by sequential enzymatic steps. Thymidine phosphorylase (TP) is the final enzyme responsible for Capecitabine activation. Studies have demonstrated that high intratumoral levels of TP and low levels of its catabolite dihydropyrimidine-dehydrogenase are correlated with the capecitabine response. The penetration of Capecitabine across the brain-blood barrier remains unknown; we report the case of and discuss a breast cancer patient who had an interesting response of brain metastases with Capecitabine in monochemotherapy before brain irradiation.
KW - Brain metastasis
KW - Capecitabine breast cancer
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U2 - 10.1080/07357900600705805
DO - 10.1080/07357900600705805
M3 - Article
C2 - 16777702
AN - SCOPUS:33745317987
VL - 24
SP - 466
EP - 468
JO - Cancer Investigation
JF - Cancer Investigation
SN - 0735-7907
IS - 4
ER -