Dramatic response to levetiracetam in post-ischaemic Holmes' tremor

P. Striano, Andrea Elefante, Antonietta Coppola, Fabio Tortora, Federico Zara, Carlo Minetti

Research output: Contribution to journalArticlepeer-review


Holmes' tremor refers to an unusual combination of rest, postural and kinetic tremor of extremities. Common causes of Holmes' tremor include stroke, trauma, vascular malformations and multiple sclerosis, with lesions involving the thalamus, brain stem or cerebellum. Although some drugs (eg, levodopa and dopaminergic drugs, clonazepam and propranolol) have been occasionally reported to give some benefit, medical treatment of Holmes' tremor is unsatisfactory, and many patients require thalamic surgery to achieve satisfactory control. We report a patient in whom post-ischaemic Holmes' tremor dramatically responded to levetiracetam treatment.

Original languageEnglish
JournalBMJ Case Reports
Publication statusPublished - Jan 23 2009

ASJC Scopus subject areas

  • Medicine(all)

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