Dravet syndrome: Treatment options and management of prolonged seizures

J Helen Cross, Roberto H Caraballo, Rima Nabbout, Federico Vigevano, Renzo Guerrini, Lieven Lagae

Research output: Contribution to journalArticle

Abstract

Over time, with careful delineation of Dravet syndrome, we have gained experience in treatments most likely to lead to improvement in seizures, as well as those that should be avoided. Sodium valproate, clobazam, stiripentol, and topiramate are all medications that may lead to benefit, as well as the ketogenic diet. Bromides may be utilized in resistant cases. However, equally important are outlining prompt rescue treatment for prolonged seizures and avoidance of precipitants. Newer agents including cannabidiol and fenfluramine have been demonstrated to be of benefit in clinical trials. We propose an algorithm for management, but appreciate that the positioning of newer agents is yet to be established.

Original languageEnglish
Pages (from-to)S39-S48
JournalEpilepsia
Volume60 Suppl 3
DOIs
Publication statusPublished - Dec 2019

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