DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine

Barbara Gelao, Leonardo Fazio, Pierluigi Selvaggi, Annabella Di Giorgio, Paolo Taurisano, Tiziana Quarto, Raffaella Romano, Annamaria Porcelli, Marina Mancini, Rita Masellis, Gianluca Ursini, Giuseppe De Simeis, Grazia Caforio, Laura Ferranti, Luciana Lo Bianco, Antonio Rampino, Orlando Todarello, Teresa Popolizio, Giuseppe Blasi, Alessandro Bertolino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rationale: Pharmacological stimulation of D2 receptors modulates prefrontal neural activity associated with working memory (WM) processing. The T allele of a functional single-nucleotide polymorphism (SNP) within DRD2 (rs1076560 G > T) predicts reduced relative expression of the D2S receptor isoform and less efficient neural cortical responses during WM tasks. Objective: We used functional MRI to test the hypothesis that DRD2 rs1076560 genotype interacts with pharmacological stimulation of D2 receptors with bromocriptine on prefrontal responses during different loads of a spatial WM task (N-Back). Methods: Fifty-three healthy subjects (38 GG and 15 GT) underwent two 3-T functional MRI scans while performing the 1-, 2- and 3-Back versions of the N-Back WM task. Before the imaging sessions, either bromocriptine or placebo was administered to all subjects in a counterbalanced order. A factorial repeated-measures ANOVA within SPM8 (p

Original languageEnglish
Pages (from-to)2361-2370
Number of pages10
JournalPsychopharmacology
Volume231
Issue number11
DOIs
Publication statusPublished - 2014

Fingerprint

Bromocriptine
Short-Term Memory
Genotype
Magnetic Resonance Imaging
Pharmacology
Single Nucleotide Polymorphism
Analysis of Variance
Healthy Volunteers
Protein Isoforms
Alleles
Placebos

Keywords

  • Bromocriptine
  • Dopamine
  • DRD2 rs1076560
  • fMRI
  • Prefrontal cortex
  • Working memory

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine. / Gelao, Barbara; Fazio, Leonardo; Selvaggi, Pierluigi; Di Giorgio, Annabella; Taurisano, Paolo; Quarto, Tiziana; Romano, Raffaella; Porcelli, Annamaria; Mancini, Marina; Masellis, Rita; Ursini, Gianluca; De Simeis, Giuseppe; Caforio, Grazia; Ferranti, Laura; Lo Bianco, Luciana; Rampino, Antonio; Todarello, Orlando; Popolizio, Teresa; Blasi, Giuseppe; Bertolino, Alessandro.

In: Psychopharmacology, Vol. 231, No. 11, 2014, p. 2361-2370.

Research output: Contribution to journalArticle

Gelao, B, Fazio, L, Selvaggi, P, Di Giorgio, A, Taurisano, P, Quarto, T, Romano, R, Porcelli, A, Mancini, M, Masellis, R, Ursini, G, De Simeis, G, Caforio, G, Ferranti, L, Lo Bianco, L, Rampino, A, Todarello, O, Popolizio, T, Blasi, G & Bertolino, A 2014, 'DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine', Psychopharmacology, vol. 231, no. 11, pp. 2361-2370. https://doi.org/10.1007/s00213-013-3398-9
Gelao, Barbara ; Fazio, Leonardo ; Selvaggi, Pierluigi ; Di Giorgio, Annabella ; Taurisano, Paolo ; Quarto, Tiziana ; Romano, Raffaella ; Porcelli, Annamaria ; Mancini, Marina ; Masellis, Rita ; Ursini, Gianluca ; De Simeis, Giuseppe ; Caforio, Grazia ; Ferranti, Laura ; Lo Bianco, Luciana ; Rampino, Antonio ; Todarello, Orlando ; Popolizio, Teresa ; Blasi, Giuseppe ; Bertolino, Alessandro. / DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine. In: Psychopharmacology. 2014 ; Vol. 231, No. 11. pp. 2361-2370.
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AU - Selvaggi, Pierluigi

AU - Di Giorgio, Annabella

AU - Taurisano, Paolo

AU - Quarto, Tiziana

AU - Romano, Raffaella

AU - Porcelli, Annamaria

AU - Mancini, Marina

AU - Masellis, Rita

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AU - De Simeis, Giuseppe

AU - Caforio, Grazia

AU - Ferranti, Laura

AU - Lo Bianco, Luciana

AU - Rampino, Antonio

AU - Todarello, Orlando

AU - Popolizio, Teresa

AU - Blasi, Giuseppe

AU - Bertolino, Alessandro

PY - 2014

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N2 - Rationale: Pharmacological stimulation of D2 receptors modulates prefrontal neural activity associated with working memory (WM) processing. The T allele of a functional single-nucleotide polymorphism (SNP) within DRD2 (rs1076560 G > T) predicts reduced relative expression of the D2S receptor isoform and less efficient neural cortical responses during WM tasks. Objective: We used functional MRI to test the hypothesis that DRD2 rs1076560 genotype interacts with pharmacological stimulation of D2 receptors with bromocriptine on prefrontal responses during different loads of a spatial WM task (N-Back). Methods: Fifty-three healthy subjects (38 GG and 15 GT) underwent two 3-T functional MRI scans while performing the 1-, 2- and 3-Back versions of the N-Back WM task. Before the imaging sessions, either bromocriptine or placebo was administered to all subjects in a counterbalanced order. A factorial repeated-measures ANOVA within SPM8 (p

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