DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients

C. Vitale, R. Gulli, P. Ciotti, C. Scaglione, E. Bellone, L. Avanzino, F. Lantieri, G. Abbruzzese, P. Martinelli, P. Barone, P. Mandich

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Abstract

Background: Essential tremor (ET) is the most common movement disorder worldwide. Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) receptor was found associated to ET in a French and US population. Methods: A case-control study to evaluate the association between the Ser9Gly variant and ET was performed in a cohort of 116 Italian patients with familial ET and in 158 normal controls. Results: No significant difference in allele and genotype frequencies was found between the two groups. Conclusions: These results do not support an association between DRD3 Ser9Gly and susceptibility to ET in Italian patients.

Original languageEnglish
Pages (from-to)985-987
Number of pages3
JournalEuropean Journal of Neurology
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2008

Keywords

  • D3 dopamine receptor
  • Essential tremor
  • ET
  • Ser9Gly polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Vitale, C., Gulli, R., Ciotti, P., Scaglione, C., Bellone, E., Avanzino, L., Lantieri, F., Abbruzzese, G., Martinelli, P., Barone, P., & Mandich, P. (2008). DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients. European Journal of Neurology, 15(9), 985-987. https://doi.org/10.1111/j.1468-1331.2008.02164.x