DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population

Alessandro Serretti, Cristina Lorenzi, Laura Mandelli, Sven Cichon, Johannes Schumacher, Markus M. Nöthen, Marcella Rietschel, Monja Tullius, Stephanie Ohlraun

Research output: Contribution to journalArticlepeer-review


We previously reported an association of DRD4 exon 3 long alleles with delusional symptomatology, independently from psychiatric diagnoses [Am. J. Med. Genet. 105 (2001) 283; Psychiatry Res. 80 (1998) 129]. The aim of this investigation was to replicate these results in an independent sample from Germany. We studied 394 subjects, affected by bipolar disorder (n = 32), schizoaffective disorder (n = 45), and schizophrenia (n = 317). All affected subjects were evaluated using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DRD4 variants were not associated with symptomatology of major psychosis. Our present results, obtained in an independent German sample, did not confirm the association between DRD4 variants and delusional symptomatology. However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Sep 30 2004


  • Dopamine receptors
  • Genetics
  • Manic depressive disorder
  • Mood disorders
  • Phenotype
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)


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