TY - JOUR
T1 - DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population
AU - Serretti, Alessandro
AU - Lorenzi, Cristina
AU - Mandelli, Laura
AU - Cichon, Sven
AU - Schumacher, Johannes
AU - Nöthen, Markus M.
AU - Rietschel, Marcella
AU - Tullius, Monja
AU - Ohlraun, Stephanie
PY - 2004/9/30
Y1 - 2004/9/30
N2 - We previously reported an association of DRD4 exon 3 long alleles with delusional symptomatology, independently from psychiatric diagnoses [Am. J. Med. Genet. 105 (2001) 283; Psychiatry Res. 80 (1998) 129]. The aim of this investigation was to replicate these results in an independent sample from Germany. We studied 394 subjects, affected by bipolar disorder (n = 32), schizoaffective disorder (n = 45), and schizophrenia (n = 317). All affected subjects were evaluated using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DRD4 variants were not associated with symptomatology of major psychosis. Our present results, obtained in an independent German sample, did not confirm the association between DRD4 variants and delusional symptomatology. However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy.
AB - We previously reported an association of DRD4 exon 3 long alleles with delusional symptomatology, independently from psychiatric diagnoses [Am. J. Med. Genet. 105 (2001) 283; Psychiatry Res. 80 (1998) 129]. The aim of this investigation was to replicate these results in an independent sample from Germany. We studied 394 subjects, affected by bipolar disorder (n = 32), schizoaffective disorder (n = 45), and schizophrenia (n = 317). All affected subjects were evaluated using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DRD4 variants were not associated with symptomatology of major psychosis. Our present results, obtained in an independent German sample, did not confirm the association between DRD4 variants and delusional symptomatology. However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy.
KW - Dopamine receptors
KW - Genetics
KW - Manic depressive disorder
KW - Mood disorders
KW - Phenotype
KW - Polymorphism
KW - Schizophrenia
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U2 - 10.1016/j.neulet.2004.06.036
DO - 10.1016/j.neulet.2004.06.036
M3 - Article
C2 - 15364409
AN - SCOPUS:4544329457
VL - 368
SP - 269
EP - 273
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -