DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population

Alessandro Serretti; Cristina Lorenzi; Laura Mandelli; Sven Cichon; Johannes Schumacher; Markus M. Nöthen; Marcella Rietschel; Monja Tullius; Stephanie Ohlraun

doi:10.1016/j.neulet.2004.06.036

DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population

Alessandro Serretti, Cristina Lorenzi, Laura Mandelli, Sven Cichon, Johannes Schumacher, Markus M. Nöthen, Marcella Rietschel, Monja Tullius, Stephanie Ohlraun

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We previously reported an association of DRD4 exon 3 long alleles with delusional symptomatology, independently from psychiatric diagnoses [Am. J. Med. Genet. 105 (2001) 283; Psychiatry Res. 80 (1998) 129]. The aim of this investigation was to replicate these results in an independent sample from Germany. We studied 394 subjects, affected by bipolar disorder (n = 32), schizoaffective disorder (n = 45), and schizophrenia (n = 317). All affected subjects were evaluated using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DRD4 variants were not associated with symptomatology of major psychosis. Our present results, obtained in an independent German sample, did not confirm the association between DRD4 variants and delusional symptomatology. However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	Neuroscience Letters
Volume	368
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2004.06.036
Publication status	Published - Sep 30 2004

Keywords

Dopamine receptors
Genetics
Manic depressive disorder
Mood disorders
Phenotype
Polymorphism
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population. / Serretti, Alessandro; Lorenzi, Cristina; Mandelli, Laura; Cichon, Sven; Schumacher, Johannes; Nöthen, Markus M.; Rietschel, Marcella; Tullius, Monja; Ohlraun, Stephanie.

In: Neuroscience Letters, Vol. 368, No. 3, 30.09.2004, p. 269-273.

Research output: Contribution to journal › Article › peer-review

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abstract = "We previously reported an association of DRD4 exon 3 long alleles with delusional symptomatology, independently from psychiatric diagnoses [Am. J. Med. Genet. 105 (2001) 283; Psychiatry Res. 80 (1998) 129]. The aim of this investigation was to replicate these results in an independent sample from Germany. We studied 394 subjects, affected by bipolar disorder (n = 32), schizoaffective disorder (n = 45), and schizophrenia (n = 317). All affected subjects were evaluated using the Operational Criteria for Psychotic Illness (OPCRIT) checklist. DRD4 variants were not associated with symptomatology of major psychosis. Our present results, obtained in an independent German sample, did not confirm the association between DRD4 variants and delusional symptomatology. However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy.",

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AU - Schumacher, Johannes

AU - Nöthen, Markus M.

AU - Rietschel, Marcella

AU - Tullius, Monja

AU - Ohlraun, Stephanie

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