Driving to Cancer on a Four-Lane Expressway

L. Galluzzi, I. Vitale

Research output: Contribution to journalArticlepeer-review


Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.
Original languageEnglish
Pages (from-to)491-492
Number of pages2
JournalTrends in Genetics
Issue number8
Publication statusPublished - Aug 1 2017


  • aneuploidy
  • chromosomal instability
  • non-small cell lung carcinoma
  • p53
  • tetraploidy

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