Epileptic negative myoclonus is characterized by brief focal or multifocal postural lapses. These correspond to muscular silent periods of 100 to 400 msec duration, time-locked with contralateral central or vertex sharp waves. The involvement of lower limbs can cause sudden falls. We studied 3 patients with partial seizures and epileptic negative myoclonus with falls. Muscular inhibition were localized in the lower limbs in one patient and were multifocal in the other two. The severity of the disorder was variable. In two patients, muscular inhibitions and falls were medically resistant and were frequent and persistent enough to make standing and walking impossible for long periods. In another patient silent periods and falls only occurred with lowering of valproate levels. Drop attacks due to epileptic negative myoclonus do not present a uniform clinical semeiology but are easily differentiated from seizures with falling provoked by other mechanisms.
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Clinical Neurology