Translated title of the contribution: Drop attacks related to focal muscular silent periods in the epileptic negative myoclonus

R. Guerini, C. Dravet, P. Genton, M. Bureau, J. Roger, G. Rubboli, C. A. Tassinari

Research output: Contribution to journalArticle


Epileptic negative myoclonus is characterized by brief focal or multifocal postural lapses. These correspond to muscular silent periods of 100 to 400 msec duration, time-locked with contralateral central or vertex sharp waves. The involvement of lower limbs can cause sudden falls. We studied 3 patients with partial seizures and epileptic negative myoclonus with falls. Muscular inhibition were localized in the lower limbs in one patient and were multifocal in the other two. The severity of the disorder was variable. In two patients, muscular inhibitions and falls were medically resistant and were frequent and persistent enough to make standing and walking impossible for long periods. In another patient silent periods and falls only occurred with lowering of valproate levels. Drop attacks due to epileptic negative myoclonus do not present a uniform clinical semeiology but are easily differentiated from seizures with falling provoked by other mechanisms.

Original languageItalian
Pages (from-to)49-50
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number82-83
Publication statusPublished - 1993


ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Guerini, R., Dravet, C., Genton, P., Bureau, M., Roger, J., Rubboli, G., & Tassinari, C. A. (1993). CADUTE DA INIBIZIONE MUSCOLARE FOCALE NEL MIOCLONO NEGATIVO EPILETTICO. Bollettino - Lega Italiana contro l'Epilessia, (82-83), 49-50.