A large amount of substances and their association can lead to worsening of latent or active cardiovascular diseases and, sometimes, to ex-novo cardiovascular diseases. Negative cardiovascular effects are mainly due to pharmacokinetics of substances, in particular if drugs are administered in combination, or if intake, distribution, and elimination processes are altered; moreover, negative effects can be due to pharmacodynamics of drugs as in the presence of an interaction between an otherwise non-toxic substance and a morphofunctional altered cardiac substrate. In the first part of this chapter, we systematically describe cardiovascular effects of illicit drugs, as listed by the World Anti-Doping Agency and including different classes of substances, namely, anabolic androgenic steroids, hormones and related substances, β2-agonists, diuretics, stimulants, narcotics, cannabinoids, glucocorticosteroids, alcohol, and β-blockers. The second part is dedicated to cardiovascular effects that can occur during the use and abuse of most common prescription drugs as antipsychotic, antibiotics, anti-viral, antihistaminic, and antineoplastic drugs.
|Title of host publication||Drug Abuse and Addiction in Medical Illness: Causes, Consequences and Treatment|
|Publisher||Springer New York|
|Number of pages||14|
|ISBN (Print)||9781461433750, 1461433746, 9781461433743|
|Publication status||Published - Jul 1 2012|
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