Drug allergy in children: Focus on beta-lactams and NSAIDs

Claudio Cravidi, Silvia Caimmi, Maria De Filippo, Alberto Martelli, Carlo Caffarelli, Michele Miraglia Del Giudice, Mauro Calvani, Maria Angela Tosca, Fabio Cardinale, Gian Luigi Marseglia, Sara Manti, Elena Chiappini, Davide Caimmi

Research output: Contribution to journalReview articlepeer-review


Drug hypersensitivity reactions (DHRs) are adverse reactions to a drug. In children, most common drugs inducing such reactions include beta-lactams (BLs) and non-steroidal anti-inflammatory drugs (NSAIDs). The aim of the present work was to provide current knowledge on the management of DHRs in the pediatric population, focusing on BLs and NSAIDs hypersensitivity. The clinical feature of DHRs include immediate and non-immediate (delayed and accelerated) reactions, that may be severe or non-severe. A systematic approach to the patient based on the reported clinical history is essential to organize a safe and adapted allergy work-up. Skin tests are the first step to assess a possible DHRs, especially in immediate reactions to BLs. Drugs concentrations for these tests are standardized and validated. The drug provocation test remains the gold standard to reach a firm diagnosis. In selected cases, a therapeutic desensitization protocol may be proposed in children with a confirmed diagnosis of drug hypersensitivity. Clinicians should be aware of the diagnostic and therapeutic options, to provide the best management in children having experienced a history of DHR. (www.actabiomedica.it).

Original languageEnglish
Article numbere2020008
Pages (from-to)1-8
Number of pages8
JournalActa Biomedica
Publication statusPublished - 2020


  • Beta-lactams
  • Children
  • Drug allergy
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Medicine(all)


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