Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing

Loredana Sarmati; Emanuele Nicastri; Ilaria Uccella; Gabriella D'Ettorre; Saverio G. Parisi; Lucia Palmisano; Clementina Galluzzo; Ercole Concia; Vincenzo Vullo; Stefano Vella; Massimo Andreoni

doi:10.1128/JCM.41.4.1760-1762.2003

Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing

Loredana Sarmati, Emanuele Nicastri, Ilaria Uccella, Gabriella D'Ettorre, Saverio G. Parisi, Lucia Palmisano, Clementina Galluzzo, Ercole Concia, Vincenzo Vullo, Stefano Vella, Massimo Andreoni

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found (k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.

Original language	English
Pages (from-to)	1760-1762
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1128/JCM.41.4.1760-1762.2003
Publication status	Published - Apr 1 2003

ASJC Scopus subject areas

Microbiology (medical)
Microbiology

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10.1128/JCM.41.4.1760-1762.2003

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Sarmati, L., Nicastri, E., Uccella, I., D'Ettorre, G., Parisi, S. G., Palmisano, L., Galluzzo, C., Concia, E., Vullo, V., Vella, S., & Andreoni, M. (2003). Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing. Journal of Clinical Microbiology, 41(4), 1760-1762. https://doi.org/10.1128/JCM.41.4.1760-1762.2003

Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing. / Sarmati, Loredana; Nicastri, Emanuele; Uccella, Ilaria et al.

In: Journal of Clinical Microbiology, Vol. 41, No. 4, 01.04.2003, p. 1760-1762.

Research output: Contribution to journal › Article › peer-review

Sarmati, L, Nicastri, E, Uccella, I, D'Ettorre, G, Parisi, SG, Palmisano, L, Galluzzo, C, Concia, E, Vullo, V, Vella, S & Andreoni, M 2003, 'Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing', Journal of Clinical Microbiology, vol. 41, no. 4, pp. 1760-1762. https://doi.org/10.1128/JCM.41.4.1760-1762.2003

Sarmati L, Nicastri E, Uccella I, D'Ettorre G, Parisi SG, Palmisano L et al. Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing. Journal of Clinical Microbiology. 2003 Apr 1;41(4):1760-1762. doi: 10.1128/JCM.41.4.1760-1762.2003

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AU - D'Ettorre, Gabriella

AU - Parisi, Saverio G.

AU - Palmisano, Lucia

AU - Galluzzo, Clementina

AU - Concia, Ercole

AU - Vullo, Vincenzo

AU - Vella, Stefano

AU - Andreoni, Massimo

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Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing

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