Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing

Loredana Sarmati, Emanuele Nicastri, Ilaria Uccella, Gabriella D'Ettorre, Saverio G. Parisi, Lucia Palmisano, Clementina Galluzzo, Ercole Concia, Vincenzo Vullo, Stefano Vella, Massimo Andreoni

Research output: Contribution to journalArticle

Abstract

In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found (k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.

Original languageEnglish
Pages (from-to)1760-1762
Number of pages3
JournalJournal of Clinical Microbiology
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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