TY - JOUR
T1 - Drug-associated resistance mutations in plasma and peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected patients for whom highly active antiretroviral therapy is failing
AU - Sarmati, Loredana
AU - Nicastri, Emanuele
AU - Uccella, Ilaria
AU - D'Ettorre, Gabriella
AU - Parisi, Saverio G.
AU - Palmisano, Lucia
AU - Galluzzo, Clementina
AU - Concia, Ercole
AU - Vullo, Vincenzo
AU - Vella, Stefano
AU - Andreoni, Massimo
PY - 2003/4/1
Y1 - 2003/4/1
N2 - In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found (k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.
AB - In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found (k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.
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U2 - 10.1128/JCM.41.4.1760-1762.2003
DO - 10.1128/JCM.41.4.1760-1762.2003
M3 - Article
C2 - 12682180
AN - SCOPUS:12444317538
VL - 41
SP - 1760
EP - 1762
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 4
ER -