Abstract
Background: The search for a drug delivery system is a highly desirable target when toxic drugs are considered (e.g. chemotherapeutics) or when the site of action of a drug is difficult to approach due to the pharmacokinetic profile of the chosen therapeutic agent. Objective: Among the different delivery systems, those based on natural or semi-synthetic polysaccharides are very promising, due to their biocompatibility and biodegradability. Up to now, different polysaccharides are investigated, mainly based on chitosan, alginic acid, dextran and hyaluronic acid. Method: These compounds are easily chemically modified, so that derivatives able to form nanoparticles or micro vector by interaction with other chemicals (e.g. by ionotropic gelation). These delivery systems can be loaded with the drug of interest in a way that dramatically change its pharmacokinetic profile, and further derivatization with molecules that selectively target the site of interest (e.g. neoplastic cells) is possible. Results and Conclusion: In this review, we describe the stateof–the-art of polysaccharide-based biopolymeric drug delivery systems developed into the last ten years, with a particular attention to the most commonly used polysaccharides (dextran, chitosan, hyaluronic acid, alginic acid), the chemical derivatization procedures and the perspective use of the obtained vehicles in clinical medicine.
| Original language | English |
|---|---|
| Pages (from-to) | 1157-1192 |
| Number of pages | 36 |
| Journal | Current Organic Chemistry |
| Volume | 22 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
Fingerprint
Keywords
- Alginate
- Anti-cancer drugs
- Chitosan
- Dextran
- Hyaluronic acid
- Nanoparticles
- Polysaccharide
- Targeted drug delivery
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Drug delivery systems for chemotherapeutics through selected polysaccharidic vehicles. / Merli, Daniele; Profumo, Antonella; Quadrelli, Paolo; Arciola, Carla Renata; Visai, Livia.
In: Current Organic Chemistry, Vol. 22, No. 12, 01.01.2018, p. 1157-1192.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Drug delivery systems for chemotherapeutics through selected polysaccharidic vehicles
AU - Merli, Daniele
AU - Profumo, Antonella
AU - Quadrelli, Paolo
AU - Arciola, Carla Renata
AU - Visai, Livia
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: The search for a drug delivery system is a highly desirable target when toxic drugs are considered (e.g. chemotherapeutics) or when the site of action of a drug is difficult to approach due to the pharmacokinetic profile of the chosen therapeutic agent. Objective: Among the different delivery systems, those based on natural or semi-synthetic polysaccharides are very promising, due to their biocompatibility and biodegradability. Up to now, different polysaccharides are investigated, mainly based on chitosan, alginic acid, dextran and hyaluronic acid. Method: These compounds are easily chemically modified, so that derivatives able to form nanoparticles or micro vector by interaction with other chemicals (e.g. by ionotropic gelation). These delivery systems can be loaded with the drug of interest in a way that dramatically change its pharmacokinetic profile, and further derivatization with molecules that selectively target the site of interest (e.g. neoplastic cells) is possible. Results and Conclusion: In this review, we describe the stateof–the-art of polysaccharide-based biopolymeric drug delivery systems developed into the last ten years, with a particular attention to the most commonly used polysaccharides (dextran, chitosan, hyaluronic acid, alginic acid), the chemical derivatization procedures and the perspective use of the obtained vehicles in clinical medicine.
AB - Background: The search for a drug delivery system is a highly desirable target when toxic drugs are considered (e.g. chemotherapeutics) or when the site of action of a drug is difficult to approach due to the pharmacokinetic profile of the chosen therapeutic agent. Objective: Among the different delivery systems, those based on natural or semi-synthetic polysaccharides are very promising, due to their biocompatibility and biodegradability. Up to now, different polysaccharides are investigated, mainly based on chitosan, alginic acid, dextran and hyaluronic acid. Method: These compounds are easily chemically modified, so that derivatives able to form nanoparticles or micro vector by interaction with other chemicals (e.g. by ionotropic gelation). These delivery systems can be loaded with the drug of interest in a way that dramatically change its pharmacokinetic profile, and further derivatization with molecules that selectively target the site of interest (e.g. neoplastic cells) is possible. Results and Conclusion: In this review, we describe the stateof–the-art of polysaccharide-based biopolymeric drug delivery systems developed into the last ten years, with a particular attention to the most commonly used polysaccharides (dextran, chitosan, hyaluronic acid, alginic acid), the chemical derivatization procedures and the perspective use of the obtained vehicles in clinical medicine.
KW - Alginate
KW - Anti-cancer drugs
KW - Chitosan
KW - Dextran
KW - Hyaluronic acid
KW - Nanoparticles
KW - Polysaccharide
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85052829584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052829584&partnerID=8YFLogxK
U2 - 10.2174/1385272822666180122161444
DO - 10.2174/1385272822666180122161444
M3 - Review article
AN - SCOPUS:85052829584
VL - 22
SP - 1157
EP - 1192
JO - Current Organic Chemistry
JF - Current Organic Chemistry
SN - 1385-2728
IS - 12
ER -