Abstract
Background and Aim: Solid demonstrations of superior efficacy of drug-eluting beads transarterial chemoembolization with respect to conventional chemoembolization in hepatocellular carcinoma patients are lacking. The aim of the study was to compare these two techniques in two large cohorts of unresectable hepatocellular carcinoma patients. Methods: A single center series of 249 early/intermediate hepatocellular carcinoma patients who underwent "on demand" chemoembolization in the period 2007-2011 was analyzed. Overall survival, time to progression, tumor response rate, and safety were compared between 104 patients who underwent conventional chemoembolization and 145 who underwent drug-eluting beads chemoembolization. Time-to-event data were analyzed using the Cox univariate and multivariate regression. Results: The two cohorts resulted balanced for liver function and tumor stages. Objective response rate was 85.3% after conventional and 74.8% after drug-eluting beads chemoembolization (P=0.039), and median time to progression was 17 (95% confidence interval: 14-21) versus 11months (9-12), respectively (P
| Original language | English |
|---|---|
| Pages (from-to) | 645-653 |
| Number of pages | 9 |
| Journal | Journal of Gastroenterology and Hepatology |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2016 |
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Keywords
- DEB-TACE
- HCC
- Hepatocellular carcinoma
- Loco-regional treatments
- TACE
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma. / Facciorusso, Antonio; Mariani, Luigi; Sposito, Carlo; Spreafico, Carlo; Bongini, Marco; Morosi, Carlo; Cascella, Tommaso; Marchianò, Alfonso; Camerini, Tiziana; Bhoori, Sherrie; Brunero, Federica; Barone, Michele; Mazzaferro, Vincenzo.
In: Journal of Gastroenterology and Hepatology, Vol. 31, No. 3, 01.03.2016, p. 645-653.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma
AU - Facciorusso, Antonio
AU - Mariani, Luigi
AU - Sposito, Carlo
AU - Spreafico, Carlo
AU - Bongini, Marco
AU - Morosi, Carlo
AU - Cascella, Tommaso
AU - Marchianò, Alfonso
AU - Camerini, Tiziana
AU - Bhoori, Sherrie
AU - Brunero, Federica
AU - Barone, Michele
AU - Mazzaferro, Vincenzo
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background and Aim: Solid demonstrations of superior efficacy of drug-eluting beads transarterial chemoembolization with respect to conventional chemoembolization in hepatocellular carcinoma patients are lacking. The aim of the study was to compare these two techniques in two large cohorts of unresectable hepatocellular carcinoma patients. Methods: A single center series of 249 early/intermediate hepatocellular carcinoma patients who underwent "on demand" chemoembolization in the period 2007-2011 was analyzed. Overall survival, time to progression, tumor response rate, and safety were compared between 104 patients who underwent conventional chemoembolization and 145 who underwent drug-eluting beads chemoembolization. Time-to-event data were analyzed using the Cox univariate and multivariate regression. Results: The two cohorts resulted balanced for liver function and tumor stages. Objective response rate was 85.3% after conventional and 74.8% after drug-eluting beads chemoembolization (P=0.039), and median time to progression was 17 (95% confidence interval: 14-21) versus 11months (9-12), respectively (P
AB - Background and Aim: Solid demonstrations of superior efficacy of drug-eluting beads transarterial chemoembolization with respect to conventional chemoembolization in hepatocellular carcinoma patients are lacking. The aim of the study was to compare these two techniques in two large cohorts of unresectable hepatocellular carcinoma patients. Methods: A single center series of 249 early/intermediate hepatocellular carcinoma patients who underwent "on demand" chemoembolization in the period 2007-2011 was analyzed. Overall survival, time to progression, tumor response rate, and safety were compared between 104 patients who underwent conventional chemoembolization and 145 who underwent drug-eluting beads chemoembolization. Time-to-event data were analyzed using the Cox univariate and multivariate regression. Results: The two cohorts resulted balanced for liver function and tumor stages. Objective response rate was 85.3% after conventional and 74.8% after drug-eluting beads chemoembolization (P=0.039), and median time to progression was 17 (95% confidence interval: 14-21) versus 11months (9-12), respectively (P
KW - DEB-TACE
KW - HCC
KW - Hepatocellular carcinoma
KW - Loco-regional treatments
KW - TACE
UR - http://www.scopus.com/inward/record.url?scp=84959112720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959112720&partnerID=8YFLogxK
U2 - 10.1111/jgh.13147
DO - 10.1111/jgh.13147
M3 - Article
VL - 31
SP - 645
EP - 653
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 3
ER -