Drug-eluting stent use after coronary atherectomy: results from a multicentre experience – The ROTALINK I study

Bernardo Cortese, Tiziana C. Aranzulla, Cosmo Godino, Giuliano Chizzola, Dennis Zavalloni, Emanuela Tavasci, Mauro de Benedictis, Federica Ettori, Patrizia Presbitero, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


AIMS: Until now, there is no medium- to long-term clinical evidence of the best treatment after rotational atherectomy.

METHODS: From the databases of seven high-volume centres, years 2005–2010, we retrospectively analysed the long-term outcome of patients who had undergone rotational atherectomy followed by plain-balloon angioplasty or implantation of drug-eluting stent (DES) or bare metal stent (BMS). Primary endpoint was the incidence of major adverse cardiovascular events (MACE: death, myocardial infarction, target-lesion-revascularization) at longest available follow-up.

RESULTS: In this registry, we enrolled 1397 patients with 1605 lesions, followed for 28.4?±?21 months. DES-treated patients were more frequently diabetic, had more lesions treated and received a higher number of stents. In-hospital MACEs were significantly higher in DES patients (7.6 vs. 2.6 vs. 2.9%, respectively, P?=?0.0001 for both), mainly due to a higher incidence of myocardial infarction (6.4 vs. 1.2 vs. 2.1%, P?=?0.0001). The 2-year follow-up showed a significantly lower incidence of MACE in DES patients (15.1 vs. 24.2 vs. 20.8%, P?=?0.001 for both), driven by a lower incidence of target-lesion revascularization (8 vs. 14.6 vs. 13.9%, P?=?0.002). Myocardial infarction rate was lower in the DES group as well (0.4 vs. 3.1% in BMS, P?=?0.001). At multivariate analysis, BMS implantation and balloon angioplasty were independent predictors of long-term MACE. DES implantation was associated with a lower risk of long-term myocardial infarction [hazard ratio 0.15, 95% confidence interval (95% CI) 0.04–0.67] and target-lesion revascularization (hazard ratio 0.42, 95% CI 0.21–0.82). Male sex and DES use were independent predictors of the absence of MACE.

CONCLUSION: After rotational atherectomy, DES implantation appears to be a preferable strategy, as it is associated with lower long-term MACE, despite an unexpected increase in periprocedural myocardial infarction.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
Publication statusAccepted/In press - Jan 7 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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