Drug eluting stents versus bare metal stents in the treatment of saphenous vein graft disease: A systematic review and meta-analysis

Luca Testa, Pierfrancesco Agostoni, Paul Vermeersch, Giuseppe Biondi-Zoccai, William Van Gaal, Ravinay Bhindi, Emmanouil Brilakis, Roberto A. Latini, Maria Luisa Laudisa, Samuele Pizzocri, Stefania Lanotte, Nedy Brambilla, Adrian Banning, Francesco Bedogni

Research output: Contribution to journalArticle

Abstract

Aims: Treatment of saphenous vein graft (SVG) disease is still a matter of debate given the uncertainty of the available conflicting data. Our aim was to assess, by means of a meta-analytic approach, the risk/benefit profile of drug eluting stents (DES) versus bare metal stents (BMS) in the treatment of SVG disease. Methods and results: A search of relevant studies in several databases was performed. The endpoints of interest such as: major adverse events (MAE) (the combination of overall death and non-fatal myocardial infarction [AMI]), target vessel revascularisation (TVR), and target lesion revascularisation (TLR) have been calculated in-hospital and at the longest follow-up. Single endpoints and the rate of stent thrombosis (ST) were also assessed. Three randomised controlled trials and 15 registry studies were appraised, totalling 3,294 patients. During hospitalisation, there was no difference in the risk of MAE, overall death, AMI and TVR. No data were available to calculate the TLR rate. At a mean follow-up of 19.8 months, no significant differences were found in the risk of MAE and AMI. BMS were associated with a trend towards a higher risk of overall death (OR 1.32 [1,00-1.74], p=0.05, number needed to treat [NNT]=55). DES showed superiority in terms of TVR (OR 1.86 [1.33-2.61], p=0.0003, NNT=16), and TLR (OR 1.77 [1.27-2.48], p

Original languageEnglish
Pages (from-to)527-536
Number of pages10
JournalEuroIntervention
Volume6
Issue number4
Publication statusPublished - Sep 2010

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Keywords

  • Bare metal stent
  • Complex lesions
  • Drug eluting stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Testa, L., Agostoni, P., Vermeersch, P., Biondi-Zoccai, G., Van Gaal, W., Bhindi, R., Brilakis, E., Latini, R. A., Laudisa, M. L., Pizzocri, S., Lanotte, S., Brambilla, N., Banning, A., & Bedogni, F. (2010). Drug eluting stents versus bare metal stents in the treatment of saphenous vein graft disease: A systematic review and meta-analysis. EuroIntervention, 6(4), 527-536.