Drug-eluting stents vs. bare metal stents in saphenous vein graft disease: Insights from a meta-analysis of 7,090 patients

Alessandro Lupi, Eliano Pio Navarese, Maurizio Lazzero, Mara Sansa, Stefano De Servi, Antonio Serra, Angelo Sante Bongo, Antonio Buffon

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Evidence supporting the use of drug-eluting stents (DES) in saphenous vein graft (SVG) disease is uncertain. Previous studies have suggested that DES might reduce the re-intervention rate in SVG disease, with conflicting data on mortality. Thus, a meta-analysis was performed to compare outcomes of DES vs. bare metal stent (BMS) in SVG disease. Methods and Results: Medline and Web databases were searched for studies comparing DES and BMS for SVG disease, reporting rates of overall mortality, target vessel revascularization (TVR) and myocardial infarction (MI) with a follow-up of ≥6 months. The meta-analysis included 23 studies (7,090 patients). Compared with BMS, DES-treated patients had lower rates of TVR (odds ratio (OR), 0.53; confidence interval (CI), 0.39-0.72; P

Original languageEnglish
Pages (from-to)280-289
Number of pages10
JournalCirculation Journal
Volume75
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Angioplasty
  • Coronary artery bypass grafting
  • Drug-eluting stents
  • Meta-analysis
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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