Drug-eluting stents vs. bare metal stents in saphenous vein graft disease: Insights from a meta-analysis of 7,090 patients

Alessandro Lupi; Eliano Pio Navarese; Maurizio Lazzero; Mara Sansa; Stefano De Servi; Antonio Serra; Angelo Sante Bongo; Antonio Buffon

doi:10.1253/circj.CJ-10-0186

Drug-eluting stents vs. bare metal stents in saphenous vein graft disease: Insights from a meta-analysis of 7,090 patients

Alessandro Lupi, Eliano Pio Navarese, Maurizio Lazzero, Mara Sansa, Stefano De Servi, Antonio Serra, Angelo Sante Bongo, Antonio Buffon

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Evidence supporting the use of drug-eluting stents (DES) in saphenous vein graft (SVG) disease is uncertain. Previous studies have suggested that DES might reduce the re-intervention rate in SVG disease, with conflicting data on mortality. Thus, a meta-analysis was performed to compare outcomes of DES vs. bare metal stent (BMS) in SVG disease. Methods and Results: Medline and Web databases were searched for studies comparing DES and BMS for SVG disease, reporting rates of overall mortality, target vessel revascularization (TVR) and myocardial infarction (MI) with a follow-up of ≥6 months. The meta-analysis included 23 studies (7,090 patients). Compared with BMS, DES-treated patients had lower rates of TVR (odds ratio (OR), 0.53; confidence interval (CI), 0.39-0.72; P

Original language	English
Pages (from-to)	280-289
Number of pages	10
Journal	Circulation Journal
Volume	75
Issue number	2
DOIs	https://doi.org/10.1253/circj.CJ-10-0186
Publication status	Published - Feb 2011

Keywords

Angioplasty
Coronary artery bypass grafting
Drug-eluting stents
Meta-analysis
Stents

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-10-0186

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Drug-eluting stents vs. bare metal stents in saphenous vein graft disease : Insights from a meta-analysis of 7,090 patients. / Lupi, Alessandro; Navarese, Eliano Pio; Lazzero, Maurizio; Sansa, Mara; De Servi, Stefano; Serra, Antonio; Bongo, Angelo Sante; Buffon, Antonio.

In: Circulation Journal, Vol. 75, No. 2, 02.2011, p. 280-289.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: Evidence supporting the use of drug-eluting stents (DES) in saphenous vein graft (SVG) disease is uncertain. Previous studies have suggested that DES might reduce the re-intervention rate in SVG disease, with conflicting data on mortality. Thus, a meta-analysis was performed to compare outcomes of DES vs. bare metal stent (BMS) in SVG disease. Methods and Results: Medline and Web databases were searched for studies comparing DES and BMS for SVG disease, reporting rates of overall mortality, target vessel revascularization (TVR) and myocardial infarction (MI) with a follow-up of ≥6 months. The meta-analysis included 23 studies (7,090 patients). Compared with BMS, DES-treated patients had lower rates of TVR (odds ratio (OR), 0.53; confidence interval (CI), 0.39-0.72; P",

keywords = "Angioplasty, Coronary artery bypass grafting, Drug-eluting stents, Meta-analysis, Stents",

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AU - Navarese, Eliano Pio

AU - Lazzero, Maurizio

AU - Sansa, Mara

AU - De Servi, Stefano

AU - Serra, Antonio

AU - Bongo, Angelo Sante

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AB - Background: Evidence supporting the use of drug-eluting stents (DES) in saphenous vein graft (SVG) disease is uncertain. Previous studies have suggested that DES might reduce the re-intervention rate in SVG disease, with conflicting data on mortality. Thus, a meta-analysis was performed to compare outcomes of DES vs. bare metal stent (BMS) in SVG disease. Methods and Results: Medline and Web databases were searched for studies comparing DES and BMS for SVG disease, reporting rates of overall mortality, target vessel revascularization (TVR) and myocardial infarction (MI) with a follow-up of ≥6 months. The meta-analysis included 23 studies (7,090 patients). Compared with BMS, DES-treated patients had lower rates of TVR (odds ratio (OR), 0.53; confidence interval (CI), 0.39-0.72; P

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Drug-eluting stents vs. bare metal stents in saphenous vein graft disease: Insights from a meta-analysis of 7,090 patients

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Keywords

ASJC Scopus subject areas

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