Drug induced exfoliative dermatitis: State of the art

Mona Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis, Giselda Colombo

Research output: Contribution to journalArticlepeer-review


Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.

Original languageEnglish
Article number9
JournalClinical and Molecular Allergy
Issue number1
Publication statusPublished - Aug 22 2016


  • Clinical features
  • Delayed type hypersensitivity
  • Drug hypersensitivity
  • Erythema multiforme
  • Exfoliative dermatitis
  • Lyell's syndrome
  • Pathogenesis
  • Stevens-Johnson syndrome
  • Therapy
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology


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