Ildanno epatico da farmaci nel bambino

Translated title of the contribution: Drug-induced liver injury in childhood

Giuseppe Maggiore, Silvia Nastasio, Francesco Cirillo, Marco Sciveres

Research output: Contribution to journalArticle

Abstract

Drug-induced liver injury (DILI) is the most common drug adverse event. Although DILI in paediatric age is relatively rare, it accounts for 20% of acute liver failure. Pathogenetic mechanisms are mostly idiosyncratic and therefore unpredictable and they mimic all forms of acute and chronic hepatobiliary diseases. Diagnosis can be difficult and a high degree of suspicion should be maintained. The most common drugs leading to DILI are acetaminophen, with a dose-dependent liver toxicity, anti-tuberculosis drugs, central nervous system agents, and anti-neoplastic drugs. Recently synthetic psychoactive drugs (Ecstasy) and herbal and dietary supplements have an increasing role in adolescent DILI.

Original languageItalian
Pages (from-to)508-513
Number of pages6
JournalMedico e Bambino
Volume31
Issue number8
Publication statusPublished - Oct 2012

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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