Drug-induced liver injury: Is it somehow foreseeable?

Giovanni Tarantino, Matteo Nicola Dario Di Minno, Domenico Capone

Research output: Contribution to journalArticle

Abstract

The classic view on the pathogenesis of drug-induced liver injury is that the so-called parent compounds are made hepatotoxic by metabolism (formation of neo-substances that react abnormally), mainly by cytochromes P-450 (CYP), with further pathways, such as mitochondrial dysfunction and apoptosis, also playing a role. Risk factors for drug-induced liver injury include concomitant hepatic diseases, age and genetic polymorphisms of CYP. However, some susceptibility can today be predicted before drug administration, working on the common substrate, by phenotyping and genotyping studies and by taking in consideration patients' health status. Physicians should always think of this adverse effect in the absence of other clear hepatic disease. Ethical and legal problems towards operators in the health care system are always matters to consider.

Original languageEnglish
Pages (from-to)2817-2833
Number of pages17
JournalWorld Journal of Gastroenterology
Volume15
Issue number23
DOIs
Publication statusPublished - Jun 21 2009

Keywords

  • Cytochrome P-450
  • Drug metabolism
  • Drug-induced liver injury
  • Herbal remedies
  • Pharmacogenomics

ASJC Scopus subject areas

  • Gastroenterology

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