The metabolism in vitro of some drug substrates (aminopyrine and oxazepam) have been studied in the rabbit during pregnancy, in the 25th day old foetus and in the newborn 30-60 min after birth. The age related differences of the drug enzyme activities of the lungs are similar to those found in liver. In the foetal organs drug metabolism is markedly reduced, compared to the adult; moreover the organs of the early newborn are less active than those of the foetus. The administration of phenobarbital or oxazepam during pregnancy significantly increases the hepatic metabolism of the substrates studied in both the adult and perinatal preparations. In contrast, no changes of the drug metabolizing activity were observed in the lungs of pretreated animals.
|Title of host publication||Farmaco, Edizione Scientifica|
|Number of pages||7|
|Publication status||Published - 1975|
ASJC Scopus subject areas
- Molecular Medicine