Drug prescribing patterns in Parkinson's disease

A pharmacoepidemiological survey in a cohort of ambulatory patients

Olivia Leoni, Emilia Martignoni, Marco Cosentino, Donatella Michielotto, Daniela Calandrella, Roberta Zangaglia, Giulio Riboldazzi, Cristina Oria, Sergio Lecchini, Giuseppe Nappi, Gianmario Frigo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose. Drug treatment of idiopathic Parkinson's disease (IPD) is a difficult task, and comorbidity and comedication add to its complexity. Since in IPD there is little information about drug use, this study investigated drug prescribing and indications in IPD patients. Methods. From June 1997 to April 1998, a cross-sectional survey of IPD outpatients was performed and demographic and clinical data and information about drug treatments was collected and analysed. Results. In the 130 IPD patients included in the study, anti-Parkinson drug (APD) prescriptions increased with disease duration and severity. Levodopa was most frequently used, followed by dopamine agonists and anticholinergic agents. Levodopa with other APDs was given to older patients with later IPD onset. Prescriptions of drugs for other indications (non-APDs) were given to 80.8% of the patients and their number increased with patient age. Non-APD prescriptions concerned mainly the circulatory system, mental disorders, the musculo-skeletal system and the digestive system. Prescriptions for indications corresponding to secondary symptoms that often complicate IPD increased with patient age and also with IPD duration. Conclusion. In IPD patients, disease duration and severity and patient age seem to be major determinants of drug use. Indications for drug prescription suggest that main comorbidity includes neuropsychiatric, circulatory, musculo-skeletal and digestive disorders. Analysis of prescribing patterns in IPD can provide a readily accessible indirect indicator of patient health status for both health services and epidemiologic research purposes.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalPharmacoepidemiology and Drug Safety
Volume11
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Drug Prescriptions
Parkinson Disease
pamidronate
Levodopa
Pharmaceutical Preparations
Comorbidity
Surveys and Questionnaires
Health Status Indicators
Digestive System
Dopamine Agents
Prescription Drugs
Health Services Research
Dopamine Agonists
Cholinergic Antagonists
Cardiovascular System
Mental Disorders
Prescriptions
Outpatients
Cross-Sectional Studies
Demography

Keywords

  • Comorbidity
  • Drug indications
  • Drug prescribing
  • Idiopathic Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Drug prescribing patterns in Parkinson's disease : A pharmacoepidemiological survey in a cohort of ambulatory patients. / Leoni, Olivia; Martignoni, Emilia; Cosentino, Marco; Michielotto, Donatella; Calandrella, Daniela; Zangaglia, Roberta; Riboldazzi, Giulio; Oria, Cristina; Lecchini, Sergio; Nappi, Giuseppe; Frigo, Gianmario.

In: Pharmacoepidemiology and Drug Safety, Vol. 11, No. 2, 2002, p. 149-157.

Research output: Contribution to journalArticle

Leoni, O, Martignoni, E, Cosentino, M, Michielotto, D, Calandrella, D, Zangaglia, R, Riboldazzi, G, Oria, C, Lecchini, S, Nappi, G & Frigo, G 2002, 'Drug prescribing patterns in Parkinson's disease: A pharmacoepidemiological survey in a cohort of ambulatory patients', Pharmacoepidemiology and Drug Safety, vol. 11, no. 2, pp. 149-157. https://doi.org/10.1002/pds.682
Leoni, Olivia ; Martignoni, Emilia ; Cosentino, Marco ; Michielotto, Donatella ; Calandrella, Daniela ; Zangaglia, Roberta ; Riboldazzi, Giulio ; Oria, Cristina ; Lecchini, Sergio ; Nappi, Giuseppe ; Frigo, Gianmario. / Drug prescribing patterns in Parkinson's disease : A pharmacoepidemiological survey in a cohort of ambulatory patients. In: Pharmacoepidemiology and Drug Safety. 2002 ; Vol. 11, No. 2. pp. 149-157.
@article{3e7bfe76b64b42d397ad50c4d80cd630,
title = "Drug prescribing patterns in Parkinson's disease: A pharmacoepidemiological survey in a cohort of ambulatory patients",
abstract = "Purpose. Drug treatment of idiopathic Parkinson's disease (IPD) is a difficult task, and comorbidity and comedication add to its complexity. Since in IPD there is little information about drug use, this study investigated drug prescribing and indications in IPD patients. Methods. From June 1997 to April 1998, a cross-sectional survey of IPD outpatients was performed and demographic and clinical data and information about drug treatments was collected and analysed. Results. In the 130 IPD patients included in the study, anti-Parkinson drug (APD) prescriptions increased with disease duration and severity. Levodopa was most frequently used, followed by dopamine agonists and anticholinergic agents. Levodopa with other APDs was given to older patients with later IPD onset. Prescriptions of drugs for other indications (non-APDs) were given to 80.8{\%} of the patients and their number increased with patient age. Non-APD prescriptions concerned mainly the circulatory system, mental disorders, the musculo-skeletal system and the digestive system. Prescriptions for indications corresponding to secondary symptoms that often complicate IPD increased with patient age and also with IPD duration. Conclusion. In IPD patients, disease duration and severity and patient age seem to be major determinants of drug use. Indications for drug prescription suggest that main comorbidity includes neuropsychiatric, circulatory, musculo-skeletal and digestive disorders. Analysis of prescribing patterns in IPD can provide a readily accessible indirect indicator of patient health status for both health services and epidemiologic research purposes.",
keywords = "Comorbidity, Drug indications, Drug prescribing, Idiopathic Parkinson's disease",
author = "Olivia Leoni and Emilia Martignoni and Marco Cosentino and Donatella Michielotto and Daniela Calandrella and Roberta Zangaglia and Giulio Riboldazzi and Cristina Oria and Sergio Lecchini and Giuseppe Nappi and Gianmario Frigo",
year = "2002",
doi = "10.1002/pds.682",
language = "English",
volume = "11",
pages = "149--157",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Drug prescribing patterns in Parkinson's disease

T2 - A pharmacoepidemiological survey in a cohort of ambulatory patients

AU - Leoni, Olivia

AU - Martignoni, Emilia

AU - Cosentino, Marco

AU - Michielotto, Donatella

AU - Calandrella, Daniela

AU - Zangaglia, Roberta

AU - Riboldazzi, Giulio

AU - Oria, Cristina

AU - Lecchini, Sergio

AU - Nappi, Giuseppe

AU - Frigo, Gianmario

PY - 2002

Y1 - 2002

N2 - Purpose. Drug treatment of idiopathic Parkinson's disease (IPD) is a difficult task, and comorbidity and comedication add to its complexity. Since in IPD there is little information about drug use, this study investigated drug prescribing and indications in IPD patients. Methods. From June 1997 to April 1998, a cross-sectional survey of IPD outpatients was performed and demographic and clinical data and information about drug treatments was collected and analysed. Results. In the 130 IPD patients included in the study, anti-Parkinson drug (APD) prescriptions increased with disease duration and severity. Levodopa was most frequently used, followed by dopamine agonists and anticholinergic agents. Levodopa with other APDs was given to older patients with later IPD onset. Prescriptions of drugs for other indications (non-APDs) were given to 80.8% of the patients and their number increased with patient age. Non-APD prescriptions concerned mainly the circulatory system, mental disorders, the musculo-skeletal system and the digestive system. Prescriptions for indications corresponding to secondary symptoms that often complicate IPD increased with patient age and also with IPD duration. Conclusion. In IPD patients, disease duration and severity and patient age seem to be major determinants of drug use. Indications for drug prescription suggest that main comorbidity includes neuropsychiatric, circulatory, musculo-skeletal and digestive disorders. Analysis of prescribing patterns in IPD can provide a readily accessible indirect indicator of patient health status for both health services and epidemiologic research purposes.

AB - Purpose. Drug treatment of idiopathic Parkinson's disease (IPD) is a difficult task, and comorbidity and comedication add to its complexity. Since in IPD there is little information about drug use, this study investigated drug prescribing and indications in IPD patients. Methods. From June 1997 to April 1998, a cross-sectional survey of IPD outpatients was performed and demographic and clinical data and information about drug treatments was collected and analysed. Results. In the 130 IPD patients included in the study, anti-Parkinson drug (APD) prescriptions increased with disease duration and severity. Levodopa was most frequently used, followed by dopamine agonists and anticholinergic agents. Levodopa with other APDs was given to older patients with later IPD onset. Prescriptions of drugs for other indications (non-APDs) were given to 80.8% of the patients and their number increased with patient age. Non-APD prescriptions concerned mainly the circulatory system, mental disorders, the musculo-skeletal system and the digestive system. Prescriptions for indications corresponding to secondary symptoms that often complicate IPD increased with patient age and also with IPD duration. Conclusion. In IPD patients, disease duration and severity and patient age seem to be major determinants of drug use. Indications for drug prescription suggest that main comorbidity includes neuropsychiatric, circulatory, musculo-skeletal and digestive disorders. Analysis of prescribing patterns in IPD can provide a readily accessible indirect indicator of patient health status for both health services and epidemiologic research purposes.

KW - Comorbidity

KW - Drug indications

KW - Drug prescribing

KW - Idiopathic Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=0036242272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036242272&partnerID=8YFLogxK

U2 - 10.1002/pds.682

DO - 10.1002/pds.682

M3 - Article

VL - 11

SP - 149

EP - 157

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - 2

ER -