Drug repurposing in oncology, an attractive opportunity for novel combinatorial regimens

Research output: Contribution to journalReview articlepeer-review

Abstract

The costs of developing, validating and buying new drugs are dramatically increasing. On the other hand, sobering economies have difficulties in sustaining their healthcare systems, particularly in countries with an elderly population requiring increasing welfare. This conundrum requires immediate action, and a possible option is to study the large, already present arsenal of drugs approved and to use them for innovative therapies. This possibility is particularly interesting in oncology, where the complexity of the cancer genome dictates in most patients a multistep therapeutic approach. In this review, we discuss a) Computational approaches; b) preclinical models; c) currently ongoing or already published clinical trials in the drug repurposing field in oncology; and d) drug repurposing to overcome resistance to previous therapies.

Original languageEnglish
Pages (from-to)2114-2136
Number of pages23
JournalCurrent Medicinal Chemistry
Volume28
Issue number11
DOIs
Publication statusPublished - 2021

Keywords

  • Computational approaches
  • Drug
  • In silico
  • Oncology
  • Preclinical models
  • Repurposing
  • Therapies

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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